Journal Article

Normal sex and age-specific parameters in a multi-ethnic population: a cardiovascular magnetic resonance study of the Canadian Alliance for Healthy Hearts and Minds cohort

Ramasundarahettige, Chinthanie, Moody, Alan, Desai, Dipika, Larose, Eric, Tardif, Jean-Claude, Vena, Jennifer, Marcotte, Francois, Broet, Philippe, Hicks, Jason, Friedrich, Matthias G., Luu, Judy M., Teixeira, Tiago, Dummer, Trevor, Awadalla, Philip, Smith, Eric E., Anand, Sonia S., Schulze, Karleen, Gebhard, Catherine, Teo, Koon K., Lee, Douglas S.

2022

Overview

Despite the growing utility of cardiovascular magnetic resonance (CMR) for cardiac morphology and function, sex and age-specific normal reference values derived from large, multi-ethnic data sets are lacking. Furthermore, most available studies use a simplified tracing methodology. Using a large cohort of participants without history of cardiovascular disease (CVD) or risk factors from the Canadian Alliance for Healthy Heart and Minds, we sought to establish a robust set of reference values for ventricular and atrial parameters using an anatomically correct contouring method, and to determine the influence of age and sex on ventricular parameters. Participants (n = 3206, 65% females; age 55.2 ± 8.4 years for females and 55.1 ± 8.8 years for men) underwent CMR using standard methods for quantitative measurements of cardiac parameters. Normal ventricular and atrial reference values are provided: (1) for males and females, (2) stratified by four age categories, and (3) for different races/ethnicities. Values are reported as absolute, indexed to body surface area, or height. Ventricular volumes and mass were significantly larger for males than females (p < 0.001). Ventricular ejection fraction was significantly diminished in males as compared to females (p < 0.001). Indexed left ventricular (LV) end-systolic, end-diastolic volumes, mass and right ventricular (RV) parameters significantly decreased as age increased for both sexes (p < 0.001). For females, but not men, mean LV and RVEF significantly increased with age (p < 0.001). Using anatomically correct contouring methodology, we provide accurate sex and age-specific normal reference values for CMR parameters derived from the largest, multi-ethnic population free of CVD to date. ClinicalTrials.gov, NCT02220582. Registered 20 August 2014—Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02220582.

• Publisher: Elsevier Inc,BioMed Central,BioMed Central Ltd,Elsevier
• Subject: Age / Age Factors / Angiology / Canada / Cardiology / Cardiovascular diseases / Cardiovascular magnetic resonance / Contouring / Disease / Electrocardiography / Female / Females / Heart / Heart diseases / Heart Ventricles - diagnostic imaging / Humans / Imaging / Magnetic resonance / Magnetic resonance imaging / Magnetic Resonance Imaging, Cine / Magnetic Resonance Spectroscopy / Male / Males / Medicine / Medicine & Public Health / Men / Middle Aged / Native North Americans / Normal / Parameters / Predictive Value of Tests / Radiology / Reference Values / Risk analysis / Risk factors / Sex / Sex differences / Sex Factors / Stroke Volume / Ventricle / Ventricular Function, Left