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Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

by Barletta, Francesca , Ghebremichael, Solomon , Kalon, Stobdan , Shamputa, Isdore Chola , Stakenas, Petras , Campos-Herrero, Isolina , Allix-Béguec, Caroline , Ballif, Marie , Fauville-Dufaux, Maryse , Willery, Eve , Kontsevaya, Irina , Shen, Adong , Blin, Camille , Beck, Hans Peter , Savic, Branislava , Rüsch-Gerdes, Sabine , Bonnet, Maryline , Borroni, Emanuele , Rastogi, Nalin , Rasmussen, Michael , Barry, Clifton E , Mona, Stefano , Augustynowicz-Kopeć, Ewa , Hanekom, Madeleine , Jiao, Wei-wei , Sanchez-Padilla, Elisabeth , Niemann, Stefan , Duforet-Frebourg, Nicolas , Cox, Helen , Diel, Roland , Lillebæk, Troels , Crudu, Valeriu , Wahl, Céline , Antierens, Annick , Toit, Kadri , Samper, Sofia , Crowe, Suzanne , Aleksic, Eman , Kohl, Thomas A , Maeda, Shinji , Varaine, Francis , Gagneux, Sébastien , Lecher, Sophie , Warren, Robin , Supply, Philip , Blum, Michael G B , Drobniewski, Francis , Wirth, Thierry , Hoffner, Sven , Cirillo, Daniela , Merker, Matthias , Sng, Li-Hwei , Nikolayevskyy, Vladyslav , Mokrousov, Igor , Vukovic, Dragana

in 45 / 45/23 / 631/326/1320 / 64 / 692/699/255/1856 / Agriculture / Animal Genetics and Genomics / Bacteriology / Biological Evolution / Biomedicine / Cancer Research / Disease transmission / Drug resistance / Evolution, Molecular / Gene Function / Genetic aspects / Genome, Bacterial / Genomes / Genotype / Global Health / Health aspects / Human Genetics / Humans / Hypotheses / Life Sciences / Microbiology and Parasitology / Mutation / Mycobacterium tuberculosis / Mycobacterium tuberculosis - classification / Mycobacterium tuberculosis - genetics / Mycobacterium tuberculosis - isolation & purification / Phylogeny / Population / Population number / Public health / Santé publique et épidémiologie / Studies / Tuberculosis / Tuberculosis, Multidrug-Resistant / Tuberculosis, Multidrug-Resistant - epidemiology / Tuberculosis, Multidrug-Resistant - microbiology

2015

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2015

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2015

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Journal Article

Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

Barletta, Francesca,

Ghebremichael, Solomon,

Kalon, Stobdan,

Shamputa, Isdore Chola,

Stakenas, Petras,

Campos-Herrero, Isolina,

Allix-Béguec, Caroline,

Ballif, Marie,

Fauville-Dufaux, Maryse,

Willery, Eve,

Kontsevaya, Irina,

Shen, Adong,

Blin, Camille,

Beck, Hans Peter,

Savic, Branislava,

Rüsch-Gerdes, Sabine,

Bonnet, Maryline,

Borroni, Emanuele,

Rastogi, Nalin,

Rasmussen, Michael,

Barry, Clifton E,

Mona, Stefano,

Augustynowicz-Kopeć, Ewa,

Hanekom, Madeleine,

Jiao, Wei-wei,

Sanchez-Padilla, Elisabeth,

Niemann, Stefan,

Duforet-Frebourg, Nicolas,

Cox, Helen,

Diel, Roland,

Lillebæk, Troels,

Crudu, Valeriu,

Wahl, Céline,

Antierens, Annick,

Toit, Kadri,

Samper, Sofia,

Crowe, Suzanne,

Aleksic, Eman,

Kohl, Thomas A,

Maeda, Shinji,

Varaine, Francis,

Gagneux, Sébastien,

Lecher, Sophie,

Warren, Robin,

Supply, Philip,

Blum, Michael G B,

Drobniewski, Francis,

Wirth, Thierry,

Hoffner, Sven,

Cirillo, Daniela,

Merker, Matthias,

Sng, Li-Hwei,

Nikolayevskyy, Vladyslav,

Mokrousov, Igor,

Vukovic, Dragana

2015

Overview

Thierry Wirth, Philip Supply, Stefan Niemann and colleagues analyze 4,987 Mycobacterium tuberculosis strains of the Beijing lineage isolated from 99 countries. They report whole-genome sequencing of 110 representative strains, characterize global population structure and reconstruct the evolutionary history of this lineage. Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ 45/23

/ 631/326/1320

/ 64

/ 692/699/255/1856

/ Agriculture

/ Animal Genetics and Genomics

/ Bacteriology