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The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
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The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
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Journal Article
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
2004
Overview
Blood vessels and nerves are complex, branched structures that share a high degree of anatomical similarity. Guidance of vessels and nerves has to be exquisitely regulated to ensure proper wiring of both systems. Several regulators of axon guidance have been identified and some of these are also expressed in endothelial cells; however, the extent to which their guidance functions are conserved in the vascular system is still incompletely understood. We show here that the repulsive netrin receptor UNC5B is expressed by endothelial tip cells of the vascular system. Disruption of the
Unc5b
gene in mice, or of
Unc5b
or
netrin-1a
in zebrafish, leads to aberrant extension of endothelial tip cell filopodia, excessive vessel branching and abnormal navigation. Netrin-1 causes endothelial filopodial retraction, but only when UNC5B is present. Thus, UNC5B functions as a repulsive netrin receptor in endothelial cells controlling morphogenesis of the vascular system.
Publisher
Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
Subject
/ Biological and medical sciences
/ Blood Vessels - abnormalities
/ Cell Movement - drug effects
/ Embryology: invertebrates and vertebrates. Teratology
/ Endothelial Cells - cytology
/ Endothelial Cells - drug effects
/ Endothelial Cells - metabolism
/ Endothelium, Vascular - cytology
/ Endothelium, Vascular - drug effects
/ Endothelium, Vascular - metabolism
/ Fundamental and applied biological sciences. Psychology
/ Genes
/ Humanities and Social Sciences
/ Mice
/ Nerve Growth Factors - genetics
/ Nerve Growth Factors - metabolism
/ Nerve Growth Factors - pharmacology
/ Netrin-1
/ Neurons
/ Organogenesis. Fetal development
/ Organogenesis. Physiological fonctions
/ Receptors, Cell Surface - genetics
/ Receptors, Cell Surface - metabolism
/ Rodents
/ Science
