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Identification and expansion of human colon-cancer-initiating cells
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Identification and expansion of human colon-cancer-initiating cells
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Journal Article
Identification and expansion of human colon-cancer-initiating cells
2007
Overview
Cancer stem cells
Two papers in this issue report the identification of a specific type of colon cancer cell that initiates tumour growth in mice. This lends support to the theory that only a few cells within a tumour, the cancer stem cells, are responsible for tumour formation and maintenance. The finding highlights the importance of finding therapeutics to target cancer stem cells.
Colon carcinoma is the second most common cause of death from cancer
1
. The isolation and characterization of tumorigenic colon cancer cells may help to devise novel diagnostic and therapeutic procedures. Although there is increasing evidence that a rare population of undifferentiated cells is responsible for tumour formation and maintenance
2
,
3
,
4
, this has not been explored for colorectal cancer. Here, we show that tumorigenic cells in colon cancer are included in the high-density CD133
+
population, which accounts for about 2.5% of the tumour cells. Subcutaneous injection of colon cancer CD133
+
cells readily reproduced the original tumour in immunodeficient mice, whereas CD133
-
cells did not form tumours. Such tumours were serially transplanted for several generations, in each of which we observed progressively faster tumour growth without significant phenotypic alterations. Unlike CD133
-
cells, CD133
+
colon cancer cells grew exponentially for more than one year
in vitro
as undifferentiated tumour spheres in serum-free medium, maintaining the ability to engraft and reproduce the same morphological and antigenic pattern of the original tumour. We conclude that colorectal cancer is created and propagated by a small number of undifferentiated tumorigenic CD133
+
cells, which should therefore be the target of future therapies.
Publisher
Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
Subject
/ Animals
/ Biological and medical sciences
/ Carcinogenesis, carcinogens and anticarcinogens
/ Colonic Neoplasms - metabolism
/ Colonic Neoplasms - pathology
/ Humanities and Social Sciences
/ Humans
/ letter
/ Mice
/ Neoplastic Stem Cells - metabolism
/ Neoplastic Stem Cells - pathology
/ Science
/ Transplantation, Heterologous
/ Tumors
