Journal Article

Functional interactions between the gut microbiota and host metabolism

Bäckhed, Fredrik, Tremaroli, Valentina

2012

Overview

The link between the microbes in the human gut and the development of obesity, cardiovascular disease and metabolic syndromes, such as type 2 diabetes, is becoming clearer. However, because of the complexity of the microbial community, the functional connections are less well understood. Studies in both mice and humans are helping to show what effect the gut microbiota has on host metabolism by improving energy yield from food and modulating dietary or the host-derived compounds that alter host metabolic pathways. Through increased knowledge of the mechanisms involved in the interactions between the microbiota and its host, we will be in a better position to develop treatments for metabolic disease.

• Publisher: Nature Publishing Group UK,Nature Publishing Group
• Subject: 631/326/2565/855 / 631/443/319 / 692/698/2741/2135 / adipose-tissue / Animals / bariatric surgery / bile-acids / Biological and medical sciences / Cardiovascular diseases / chain fatty-acids / Clinical Medicine / Diet / diet-induced obesity / Energy Metabolism / Fermentation / germ-free-mice / glucose-homeostasis / Host-bacteria relationships / Humanities and Social Sciences / Humans / Immunity, Innate / induced inflammation / Inflammation - metabolism / Inflammation - microbiology / insulin-resistance / Intestines - immunology / Intestines - metabolism / Intestines - microbiology / Klinisk medicin / Medical sciences / Metabolic diseases / Metabolic disorders / Metabolic Syndrome - metabolism / Metabolic Syndrome - microbiology / Metabolism / Metagenome - immunology / Metagenome - physiology / Microbiology / Microbiota (Symbiotic organisms) / multidisciplinary / Obesity / Obesity - metabolism / Obesity - microbiology / protein-coupled receptor / review-article / Science / Science (multidisciplinary) / Studies / Weight control