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Sequencing of Seven Haloarchaeal Genomes Reveals Patterns of Genomic Flux

by Facciotti, Marc T. , Eisen, Jonathan A. , Langille, Morgan G. I. , Darling, Aaron , Lynch, Erin A. , Haltiner, Caitlin , Starr, Michael O. , Harkins, Timothy T. , Shao, Katie S. Y. , Wilbanks, Elizabeth G. , Teiling, Clotilde , Edwards, Robert A.

in Acids / Analysis / Animal behavior / Archaea / bacterial genomics / BASIC BIOLOGICAL SCIENCES / Bioinformatics / Biology / Biomedical engineering / Biotechnology / Computer science / CRISPER / Cultivation / Deoxyribonucleic acid / DNA / DNA, Archaeal - genetics / DNA, Archaeal - metabolism / Enzymes / Functional groups / Gene Flow / Gene sequencing / Genes / Genome, Archaeal - physiology / Genomes / Genomics / Haloarcula - genetics / Haloarcula - metabolism / halobacterium / Haloferax - genetics / Haloferax - metabolism / Horizontal transfer / Laboratories / Metabolism / phylogenetic analysis / Phylogenetics / Proliferating cell nuclear antigen / Protein binding / Scaffolds / sequence alignment / Sequence Analysis, DNA / TATA-binding protein / Transcription (Genetics) / transcription factors

2012

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Sequencing of Seven Haloarchaeal Genomes Reveals Patterns of Genomic Flux

2012

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Sequencing of Seven Haloarchaeal Genomes Reveals Patterns of Genomic Flux

2012

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Journal Article

Sequencing of Seven Haloarchaeal Genomes Reveals Patterns of Genomic Flux

Facciotti, Marc T.,

Eisen, Jonathan A.,

Langille, Morgan G. I.,

Darling, Aaron,

Lynch, Erin A.,

Haltiner, Caitlin,

Starr, Michael O.,

Harkins, Timothy T.,

Shao, Katie S. Y.,

Wilbanks, Elizabeth G.,

Teiling, Clotilde,

Edwards, Robert A.

2012

Overview

We report the sequencing of seven genomes from two haloarchaeal genera, Haloferax and Haloarcula. Ease of cultivation and the existence of well-developed genetic and biochemical tools for several diverse haloarchaeal species make haloarchaea a model group for the study of archaeal biology. The unique physiological properties of these organisms also make them good candidates for novel enzyme discovery for biotechnological applications. Seven genomes were sequenced to ∼20×coverage and assembled to an average of 50 contigs (range 5 scaffolds-168 contigs). Comparisons of protein-coding gene compliments revealed large-scale differences in COG functional group enrichment between these genera. Analysis of genes encoding machinery for DNA metabolism reveals genera-specific expansions of the general transcription factor TATA binding protein as well as a history of extensive duplication and horizontal transfer of the proliferating cell nuclear antigen. Insights gained from this study emphasize the importance of haloarchaea for investigation of archaeal biology.

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Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

/ Archaea

/ BASIC BIOLOGICAL SCIENCES

/ Bioinformatics