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Comparison of BD MAX GBS and GenomEra GBS assays for rapid intrapartum PCR detection of vaginal carriage of group B streptococci
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Comparison of BD MAX GBS and GenomEra GBS assays for rapid intrapartum PCR detection of vaginal carriage of group B streptococci
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Journal Article
Comparison of BD MAX GBS and GenomEra GBS assays for rapid intrapartum PCR detection of vaginal carriage of group B streptococci
2019
Overview
To compare the diagnostic performance of BD MAX and GenomEra PCR assays for a rapid PCR detection of vaginal carriage of group B streptococci at delivery.
This is a retrospective laboratory analysis of vaginal swab samples taken intrapartum from a randomly selected cohort of pregnant women giving birth at a single childbirth and maternity unit.
Ninety-one culture-positive and 279 culture-negative vaginal samples were included from a cohort of 902 women. One-hundred-and-two specimens were found positive with the BD MAX and 84 with the GenomEra PCR assay. No statistically significant difference was observed compared to culture, sensitivity of BD MAX 84.6% (77/91) [95%CI 75.5-91.3] and of GenomEra 71.4% (65/91) [95%CI 61.0-80.4]. When compared to a combined reference standard, no statistically significant differences were seen between culture, BD MAX and GenomEra PCR assays. The sensitivities were 82.7% (91/110) [95%CI 74.3-89.3], 87.3% (96/110) [95%CI 79.6-92.9], and 79.1% (87/110) [95%CI 70.3-86.3], respectively.
Both PCR assays performed comparably to culture of the intrapartum vaginal samples. In particular, the GenomEra assay is potentially an easy and rapid on-site PCR test for intrapartum detection of vaginal carriage of group B streptococci at a maternity ward to identify women who should receive intrapartum antibiotic prophylaxis.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Assaying
/ Culture
/ DNA, Bacterial - isolation & purification
/ Female
/ Genomes
/ Humans
/ Identification and classification
/ Medicine and Health Sciences
/ Pregnancy Complications, Infectious - diagnosis
/ Pregnancy Complications, Infectious - genetics
/ Pregnancy Complications, Infectious - microbiology
/ Research and Analysis Methods
/ Samples
/ Streptococcal Infections - diagnosis
/ Streptococcal Infections - genetics
/ Streptococcal Infections - prevention & control
/ Streptococcus agalactiae - genetics
/ Studies
/ Vagina
