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An Approach for Identifying Brainstem Dopaminergic Pathways Using Resting State Functional MRI
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An Approach for Identifying Brainstem Dopaminergic Pathways Using Resting State Functional MRI
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Journal Article
An Approach for Identifying Brainstem Dopaminergic Pathways Using Resting State Functional MRI
2014
Overview
Here, we present an approach for identifying brainstem dopaminergic pathways using resting state functional MRI. In a group of healthy individuals, we searched for significant functional connectivity between dopamine-rich midbrain areas (substantia nigra; ventral tegmental area) and a striatal region (caudate) that was modulated by both a pharmacological challenge (the administration of the dopaminergic agonist bromocriptine) and a dopamine-sensitive cognitive trait (an individual's working memory capacity). A significant inverted-U shaped connectivity pattern was found in a subset of midbrain-striatal connections, demonstrating that resting state fMRI data is sufficiently powerful to identify brainstem neuromodulatory brain networks.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Biology
/ Brain
/ Bromocriptine - pharmacology
/ Caudate Nucleus - metabolism
/ Caudate Nucleus - physiology
/ Corpus Striatum - metabolism
/ Corpus Striatum - physiology
/ Dopamine
/ Dopamine Agonists - pharmacology
/ Dopaminergic Neurons - drug effects
/ Dopaminergic Neurons - physiology
/ Female
/ Functional magnetic resonance imaging
/ Humans
/ Magnetic Resonance Imaging - methods
/ Male
/ Memory
/ Neural Pathways - drug effects
/ Neural Pathways - physiology
/ Psychomotor Performance - physiology
/ Substantia Nigra - metabolism
/ Substantia Nigra - physiology
/ Ventral Tegmental Area - metabolism
