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Association between Age and the 7 Repeat Allele of the Dopamine D4 Receptor Gene
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Association between Age and the 7 Repeat Allele of the Dopamine D4 Receptor Gene
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Journal Article
Association between Age and the 7 Repeat Allele of the Dopamine D4 Receptor Gene
2016
Overview
Longevity is in part (25%) inherited, and genetic studies aim to uncover allelic variants that play an important role in prolonging life span. Results to date confirm only a few gene variants associated with longevity, while others show inconsistent results. However, GWAS studies concentrate on single nucleotide polymorphisms, and there are only a handful of studies investigating variable number of tandem repeat variations related to longevity. Recently, Grady and colleagues (2013) reported a remarkable (66%) accumulation of those carrying the 7 repeat allele of the dopamine D4 receptor gene in a large population of 90-109 years old Californian centenarians, as compared to an ancestry-matched young population. In the present study we demonstrate the same association using continuous age groups in an 18-97 years old Caucasian sample (N = 1801, p = 0.007). We found a continuous pattern of increase from 18-75, however frequency of allele 7 carriers decreased in our oldest age groups. Possible role of gene-environment interaction effects driven by historical events are discussed. In accordance with previous findings, we observed association preferentially in females (p = 0.003). Our results underlie the importance of investigating non-disease related genetic variants as inherited components of longevity, and confirm, that the 7-repeat allele of the dopamine D4 receptor gene is a longevity enabling genetic factor, accumulating in the elderly female population.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Adult
/ Age
/ Aged
/ Aging
/ Alleles
/ Analysis
/ Attention deficit hyperactivity disorder
/ Dementia
/ Dopamine
/ European Continental Ancestry Group - genetics
/ Female
/ Females
/ Gene-Environment Interaction
/ Genes
/ Genetic Association Studies - methods
/ Genomes
/ Genotype-environment interactions
/ Humans
/ Hungary
/ Male
/ Receptors, Dopamine D4 - genetics
/ Single nucleotide polymorphisms
/ Single-nucleotide polymorphism
/ Studies
