Asset Details
Do you wish to reserve the book?
Is Pesticide Use Related to Parkinson Disease? Some Clues to Heterogeneity in Study Results
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Is Pesticide Use Related to Parkinson Disease? Some Clues to Heterogeneity in Study Results
Do you wish to request the book?
Is Pesticide Use Related to Parkinson Disease? Some Clues to Heterogeneity in Study Results
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Is Pesticide Use Related to Parkinson Disease? Some Clues to Heterogeneity in Study Results
2012
Overview
Background: Previous systematic reviews have indicated that pesticide exposure is possibly associated with Parkinson disease (PD). However, considerable heterogeneity has been observed in study results. Objective: We aimed at providing an update of the literature published on PD and exposure to pesticides by performing a systematic review and meta-analysis. In addition, we investigated whether methodological differences between studies could explain the heterogeneity in study results. Methods: We identified studies through a systematic literature search. We calculated summary risk ratios (sRRs) for pesticide exposure and subcategories using random effects meta-analyses and investigated sources of heterogeneity by meta-regression and stratified analyses. Results: Thirty-nine case-control studies, four cohort studies, and three cross-sectional studies were identified. An sRR of 1.62 [95% confidence interval (CI): 1.40, 1.88] for pesticide exposure (ever vs. never) was found. Summary estimates for subclasses of pesticides indicated a positive association with herbicides and insecticides, but not with fungicides. Heterogeneity in individual study results was not related to study design, source of control population, adjustment of results for potential confbunders, or geographical area. However, results were suggestive for heterogeneity related to differences in the exposure assessment. Job title-based exposure assignment resulted in a higher sRR (2.5; 95% CI: 1.5, 4.1) than did assignment based on self-reported exposure (e.g., for self-reported ever/never exposure, sRR -1.5; 95% CI: 1.3,1.8). Conclusions: This review affirms the evidence that exposure to herbicides and insecticides increase the risk of PD. Future studies should focus on more objective and improved methods of pesticide exposure assessment.
Publisher
National Institute of Environmental Health Sciences,US Department of Health and Human Services
Subject
Biological and medical sciences
/ Environment. Living conditions
/ Environmental Pollutants - toxicity
/ Exposure
/ Humans
/ Men
/ Nervous system (semeiology, syndromes)
/ Parkinson Disease - epidemiology
/ Parkinson Disease - etiology
/ Parkinson Disease, Secondary - chemically induced
/ Parkinson Disease, Secondary - epidemiology
/ Pesticides, fertilizers and other agrochemicals toxicology
/ Public health. Hygiene-occupational medicine
/ Reviews
