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Unconventional Repertoire Profile Is Imprinted during Acute Chikungunya Infection for Natural Killer Cells Polarization toward Cytotoxicity
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Unconventional Repertoire Profile Is Imprinted during Acute Chikungunya Infection for Natural Killer Cells Polarization toward Cytotoxicity
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Journal Article
Unconventional Repertoire Profile Is Imprinted during Acute Chikungunya Infection for Natural Killer Cells Polarization toward Cytotoxicity
2011
Overview
Chikungunya virus (CHIKV) is a worldwide emerging pathogen. In humans it causes a syndrome characterized by high fever, polyarthritis, and in some cases lethal encephalitis. Growing evidence indicates that the innate immune response plays a role in controlling CHIKV infection. We show here that CHIKV induces major but transient modifications in NK-cell phenotype and function soon after the onset of acute infection. We report a transient clonal expansion of NK cells that coexpress CD94/NKG2C and inhibitory receptors for HLA-C1 alleles and are correlated with the viral load. Functional tests reveal cytolytic capacity driven by NK cells in the absence of exogenous signals and severely impaired IFN-γ production. Collectively these data provide insight into the role of this unique subset of NK cells in controlling CHIKV infection by subset-specific expansion in response to acute infection, followed by a contraction phase after viral clearance.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Adult
/ Alphavirus Infections - immunology
/ Cells
/ Chikungunya virus - immunology
/ Cytotoxicity, Immunologic - immunology
/ Female
/ Humans
/ Killer Cells, Natural - immunology
/ Lymphocyte Subsets - immunology
/ Male
/ Medicine
/ NK Cell Lectin-Like Receptor Subfamily C - immunology
/ NK Cell Lectin-Like Receptor Subfamily D - immunology
/ Receptors, Natural Killer Cell - analysis
/ Software
