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The prevention and treatment of Plasmodium vivax malaria
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Journal Article
The prevention and treatment of Plasmodium vivax malaria
2021
Overview
Frequent P. vivax infections are a major cause of morbidity in vivax malaria, particularly in young children in whom repeated relapse may cause severe anaemia, malnutrition, and growth delay [19, 20]. [...]an important goal of treatment is to prevent relapse. The diagnostic sensitivity depends on the slide quality and the experience of the microscopist. [...]under field conditions, microscopy may miss some symptomatic cases because of the low parasite densities in P. vivax infections, but overall, it is suitably sensitive and specific for clinical diagnosis. First-generation RDTs had lower sensitivities for P. vivax parasitaemia [22] and could give false positive results [23] with high-density P. falciparum infections. In Papua New Guinea, anopheline vectors changed their behaviour to bite earlier after the introduction of bed nets [35]. [...]ITNs have no direct impact against relapse, which is often the main cause of vivax malaria (and once relapse proportions exceed 50%, relapses become the main cause of P. vivax infections).
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
