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The global burden of Plasmodium vivax malaria is obscure and insidious
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The global burden of Plasmodium vivax malaria is obscure and insidious
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Journal Article
The global burden of Plasmodium vivax malaria is obscure and insidious
2021
Overview
Semi-immune older children and adults through much of endemic sub-Saharan Africa, who greatly outnumber vulnerable young children and pregnant women, are very often infected at high rates of prevalence but only rarely suffer attacks of acute malaria [7]. Whereas a diagnosis of P. falciparum came with a higher risk of death within 14 days of diagnosis, over the longer term, greater numbers of repeated attacks and hospitalizations among P. vivax patients came with risk of death that was nearly twice that among patients with P. falciparum. [...]hematopoietic niches of plasmodial asexual schizogony (and gametocytogenesis) may be less sensitive to blood schizontocides like artemisinin [47]. A study from Brazilian Amazonia described primaquine-induced acute hemolytic anemia as the dominant cause of blood transfusion [61], and some endemic nations have prohibited primaquine therapy for fear of such harm [62].
Publisher
Public Library of Science,Public Library of Science (PLoS)
