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Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

by Serghiou, Stylianos , de Wilde, Arno , Vesterinen, Hanna , Hirst, Theo , Bahor, Zsanett , Lawson McLean, Aaron , Potluru, Aparna , Churilov, Leonid , Kyriakopoulou, Aikaterini , Baginskitae, Julija , Thomson, Andrew , Sherratt, Nicki , Macleod, Malcolm R. , Nunes-Fonseca, Cristina , Hemblade, Rachel , Howells, David W. , Sena, Emily S. , Currie, Gillian L. , Egan, Kieren

in Animal diseases / Animals / Bias / Biological markers / Biological Science Disciplines - methods / Biological Science Disciplines - trends / Biomedical research / Biomedical Research - methods / Biomedical Research - standards / Biomedical Research - trends / Councils / Data Accuracy / Experiments / Funding / Guidelines as Topic / Higher education / Humans / Impact factors / Journal Impact Factor / Medical research / Periodicals as Topic - trends / Physiological aspects / Publication Bias / Quality / Quality Improvement / Science / Selection Bias / Studies / United Kingdom

2015

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2015

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Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

2015

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Journal Article

Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

Serghiou, Stylianos,

de Wilde, Arno,

Vesterinen, Hanna,

Hirst, Theo,

Bahor, Zsanett,

Lawson McLean, Aaron,

Potluru, Aparna,

Churilov, Leonid,

Kyriakopoulou, Aikaterini,

Baginskitae, Julija,

Thomson, Andrew,

Sherratt, Nicki,

Macleod, Malcolm R.,

Nunes-Fonseca, Cristina,

Hemblade, Rachel,

Howells, David W.,

Sena, Emily S.,

Currie, Gillian L.,

Egan, Kieren

2015

Overview

The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of randomisation in work published in journals of high impact, and very limited reporting of measures to reduce the risk of bias in publications from leading United Kingdom institutions. Ascertainment of differences between institutions might serve both as a measure of research quality and as a tool for institutional efforts to improve research quality.

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Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

Animal diseases

/ Animals

/ Bias

/ Biological markers

/ Biological Science Disciplines - methods

/ Biological Science Disciplines - trends

/ Biomedical research