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Outcomes 1 Year after Thrombus Aspiration for Myocardial Infarction
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Outcomes 1 Year after Thrombus Aspiration for Myocardial Infarction
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Journal Article
Outcomes 1 Year after Thrombus Aspiration for Myocardial Infarction
2014
Overview
In a randomized trial, over 7000 patients with ST-segment elevation MI were assigned to undergo thrombus aspiration followed by percutaneous coronary intervention or PCI alone. At 1 year, there was no significant between-group difference in the rate of death from any cause.
Acute ST-segment elevation myocardial infarction (STEMI) is often caused by intracoronary thrombus formation with blockage of antegrade coronary flow leading to myocardial ischemia and cell death.
1
Thrombus burden, reduced coronary flow, and reduced myocardial perfusion are important predictors of a poor clinical outcome, including recurrence of myocardial infarction, stent thrombosis, and death.
2
Prompt initiation of antithrombotic therapy in combination with percutaneous coronary intervention (PCI) is the preferred approach to optimize myocardial perfusion and clinical outcomes.
3
Coronary-artery thrombus aspiration before PCI reduces the thrombus burden and improves ST-segment resolution and coronary flow.
4
,
5
To our knowledge, however, no adequately powered randomized . . .
Publisher
Massachusetts Medical Society
Subject
/ Biological and medical sciences
/ Cardiology and Cardiovascular Disease
/ Coronary Thrombosis - therapy
/ Death
/ Female
/ Heart
/ Humans
/ Implants
/ Kardiologi och kardiovaskulära sjukdomar
/ Male
/ Myocardial Infarction - mortality
/ Myocardial Infarction - therapy
/ Myocarditis. Cardiomyopathies
/ Percutaneous Coronary Intervention
/ Radiologi och bildbehandling
/ Radiology and Medical Imaging
/ Suction
