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A review on Lactococcus lactis: from food to factory
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Journal Article
A review on Lactococcus lactis: from food to factory
2017
Overview
Lactococcus lactis
has progressed a long way since its discovery and initial use in dairy product fermentation, to its present biotechnological applications in genetic engineering for the production of various recombinant proteins and metabolites that transcends the heterologous species barrier. Key desirable features of this gram-positive lactic acid non-colonizing gut bacteria include its generally recognized as safe (GRAS) status, probiotic properties, the absence of inclusion bodies and endotoxins, surface display and extracellular secretion technology, and a diverse selection of cloning and inducible expression vectors. This have made
L. lactis
a desirable and promising host on par with other well established model bacterial or yeast systems such as
Escherichia coli, Salmonella cerevisiae
and
Bacillus subtilis
. In this article, we review recent technological advancements, challenges, future prospects and current diversified examples on the use of
L. lactis
as a microbial cell factory. Additionally, we will also highlight latest medical-based applications involving whole-cell
L. lactis
as a live delivery vector for the administration of therapeutics against both communicable and non-communicable diseases.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Bacteria
/ Chemistry and Materials Science
/ Cloning
/ Communicable Diseases - therapy
/ E coli
/ Food
/ Genetic Engineering - methods
/ Growth
/ Kinases
/ Lactococcus lactis - genetics
/ Lactococcus lactis - metabolism
/ Metabolic Engineering - methods
/ Methods
/ Microbial Genetics and Genomics
/ Plasmids
/ Probiotics - therapeutic use
/ Recombinant Proteins - biosynthesis
/ Recombinant Proteins - genetics
/ Recombinant Proteins - therapeutic use
/ Review
/ Yeast
