Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Synthetic Mammalian Prions

by Legname, Giuseppe , Riesner, Detlev , DeArmond, Stephen J. , Prusiner, Stanley B. , Cohen, Fred E. , Nguyen, Hoang-Oanh B. , Baskakov, Ilia V.

in Amyloid - chemistry / Amyloid - metabolism / Amyloids / Animals / Bacteria / Biological and medical sciences / Biopolymers / Brain / Brain - metabolism / Brain - pathology / Brain Chemistry / Creutzfeldt Jakob syndrome / Disease transmission / E coli / Escherichia coli / Escherichia coli - genetics / Female / Fundamental and applied biological sciences. Psychology / Glycosylation / Inoculation / Male / Mammals / Mice / Mice, Transgenic / Microbiology / Nervous system diseases / Neurodegenerative diseases / Neurological disorders / Non conventional transmissible agents / Pathology / Plaque, Amyloid - pathology / Prion diseases / Prion Diseases - etiology / Prion Diseases - pathology / Prion Diseases - transmission / Prions / Prions (Proteins) / Prions - administration & dosage / Prions - biosynthesis / Prions - chemistry / Prions - pathogenicity / Properties / Protein Conformation / Protein Folding / PrPSc Proteins - analysis / PrPSc Proteins - metabolism / Recombinant Proteins - administration & dosage / Recombinant Proteins - biosynthesis / Recombinant Proteins - chemistry / Solar fibrils / Time Factors / Tissue Extracts - administration & dosage / Vacuoles / Vacuoles - pathology

2004

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Synthetic Mammalian Prions

by Legname, Giuseppe , Riesner, Detlev , DeArmond, Stephen J. , Prusiner, Stanley B. , Cohen, Fred E. , Nguyen, Hoang-Oanh B. , Baskakov, Ilia V.

2004

Confirm

Do you wish to request the book?

Synthetic Mammalian Prions

by Legname, Giuseppe , Riesner, Detlev , DeArmond, Stephen J. , Prusiner, Stanley B. , Cohen, Fred E. , Nguyen, Hoang-Oanh B. , Baskakov, Ilia V.

2004

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Synthetic Mammalian Prions

Legname, Giuseppe,

Riesner, Detlev,

DeArmond, Stephen J.,

Prusiner, Stanley B.,

Cohen, Fred E.,

Nguyen, Hoang-Oanh B.,

Baskakov, Ilia V.

2004

Overview

Recombinant mouse prion protein (recMoPrP) produced in Escherichia coli was polymerized into amyloid fibrils that represent a subset of β sheet-rich structures. Fibrils consisting of recMoPrP(89-230) were inoculated intracerebrally into transgenic (Tg) mice expressing MoPrP(89-231). The mice developed neurologic dysfunction between 380 and 660 days after inoculation. Brain extracts showed protease-resistant PrP by Western blotting; these extracts transmitted disease to wild-type FVB mice and Tg mice overexpressing PrP, with incubation times of 150 and 90 days, respectively. Neuropathological findings suggest that a novel prion strain was created. Our results provide compelling evidence that prions are infectious proteins.

Share this book

Add to My Shelf

Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

Amyloid - chemistry

/ Amyloid - metabolism

/ Amyloids

/ Animals

/ Bacteria

/ Biological and medical sciences

/ Biopolymers