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Myelination and support of axonal integrity by glia
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Journal Article
Myelination and support of axonal integrity by glia
2010
Overview
The myelination of axons by glial cells was the last major step in the evolution of cells in the vertebrate nervous system, and white-matter tracts are key to the architecture of the mammalian brain. Cell biology and mouse genetics have provided insight into axon–glia signalling and the molecular architecture of the myelin sheath. Glial cells that myelinate axons were found to have a dual role by also supporting the long-term integrity of those axons. This function may be independent of myelin itself. Myelin abnormalities cause a number of neurological diseases, and may also contribute to complex neuropsychiatric disorders.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Biological and medical sciences
/ Demyelinating Diseases - pathology
/ Demyelinating Diseases - physiopathology
/ Fundamental and applied biological sciences. Psychology
/ Genetics
/ Humanities and Social Sciences
/ Humans
/ Inflammation - physiopathology
/ Neurons
/ Proteins
/ Rodents
/ Science
