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Prolonged Monkeypox Virus Infections, California, USA, May 2022–August 2024

by Jacobson, Kathleen , Saadeh, Kayla , Snyder, Robert E. , Peters, Philip , Watson, Jessica , Tang, Eric C. , Johnson, Kelly A. , Chapman, Eric , Sykes, Deanna A. , Schildhauer, Samuel

in Adolescent / Adult / African Americans / Aged / California / California - epidemiology / Child / Child, Preschool / Development and progression / Epidemics / Ethnicity / Female / Health surveillance / HIV / HIV (Viruses) / HIV Infections - epidemiology / HIV patients / Human immunodeficiency virus / Human monkeypox / Human subjects / Humans / Infection / Infections / Lesions / Male / Middle Aged / monkeypox / Monkeypox virus / Mpox / Mpox, Monkeypox - epidemiology / Mpox, Monkeypox - history / Mpox, Monkeypox - virology / MPXV / Public health / Risk factors / Sexual orientation / Smallpox / Sociodemographics / Statistics / United States / Vaccination / Vaccines / viruses / Young Adult / zoonoses

2025

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Prolonged Monkeypox Virus Infections, California, USA, May 2022–August 2024

by Jacobson, Kathleen , Saadeh, Kayla , Snyder, Robert E. , Peters, Philip , Watson, Jessica , Tang, Eric C. , Johnson, Kelly A. , Chapman, Eric , Sykes, Deanna A. , Schildhauer, Samuel

2025

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Prolonged Monkeypox Virus Infections, California, USA, May 2022–August 2024

by Jacobson, Kathleen , Saadeh, Kayla , Snyder, Robert E. , Peters, Philip , Watson, Jessica , Tang, Eric C. , Johnson, Kelly A. , Chapman, Eric , Sykes, Deanna A. , Schildhauer, Samuel

2025

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Journal Article

Prolonged Monkeypox Virus Infections, California, USA, May 2022–August 2024

Jacobson, Kathleen,

Saadeh, Kayla,

Snyder, Robert E.,

Peters, Philip,

Watson, Jessica,

Tang, Eric C.,

Johnson, Kelly A.,

Chapman, Eric,

Sykes, Deanna A.,

Schildhauer, Samuel

2025

Overview

Monkeypox virus (MPXV) infection typically lasts 14-28 days. Prolonged MPXV infection, in which symptoms or test positivity last >28 days, has been documented but not fully characterized. We used the California Department of Public Health (California, USA) mpox registry to compare prolonged (>28 days) and nonprolonged (<28 days) mpox cases by demographics, HIV status, and JYNNEOS vaccination status. Of 6,469 cases, 82 (1.3%) were prolonged. Persons with prolonged MPXV infections were more likely to be Black or African American (prolonged, 20.7%, vs. nonprolonged, 11.6%) and to have HIV (prolonged, 61.0%, vs. nonprolonged, 39.9%). Among persons with HIV, prolonged infections were more likely among those with lower (<200) CD4 counts (prolonged, 10.0%, vs. nonprolonged, 3.9%) or not engaged in HIV care (prolonged, 46.0%, vs. nonprolonged, 18.1%). No prolonged infections occurred in persons who received 2 JYNNEOS vaccine doses. Groups disproportionately affected by prolonged mpox should be prioritized for mpox vaccine education and outreach.

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Publisher

U.S. National Center for Infectious Diseases,Centers for Disease Control and Prevention

Subject

Adolescent

/ Adult

/ African Americans

/ Aged

/ California

/ California - epidemiology

/ Child