Asset Details
Do you wish to reserve the book?
Distinct Roles and Regulations for Hoxd Genes in Metanephric Kidney Development
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Distinct Roles and Regulations for Hoxd Genes in Metanephric Kidney Development
Do you wish to request the book?
Distinct Roles and Regulations for Hoxd Genes in Metanephric Kidney Development
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Distinct Roles and Regulations for Hoxd Genes in Metanephric Kidney Development
2007
Overview
Hox genes encode homeodomain-containing proteins that control embryonic development in multiple contexts. Up to 30 Hox genes, distributed among all four clusters, are expressed during mammalian kidney morphogenesis, but functional redundancy between them has made a detailed functional account difficult to achieve. We have investigated the role of the HoxD cluster through comparative molecular embryological analysis of a set of mouse strains carrying targeted genomic rearrangements such as deletions, duplications, and inversions. This analysis allowed us to uncover and genetically dissect the complex role of the HoxD cluster. Regulation of metanephric mesenchyme-ureteric bud interactions and maintenance of structural integrity of tubular epithelia are differentially controlled by some Hoxd genes during renal development, consistent with their specific expression profiles. We also provide evidence for a kidney-specific form of colinearity that underlies the differential expression of two distinct sets of genes located on both sides and overlapping at the Hoxd9 locus. These insights further our knowledge of the genetic control of kidney morphogenesis and may contribute to understanding certain congenital kidney malformations, including polycystic kidney disease and renal hypoplasia.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ DNA-Binding Proteins - deficiency
/ DNA-Binding Proteins - genetics
/ DNA-Binding Proteins - physiology
/ Female
/ Gene Expression Regulation, Developmental
/ Genes
/ Homeodomain Proteins - genetics
/ Homeodomain Proteins - physiology
/ Mice
/ Neoplasm Proteins - deficiency
/ Neoplasm Proteins - genetics
/ Neoplasm Proteins - physiology
/ Polycystic Kidney Diseases - embryology
/ Polycystic Kidney Diseases - genetics
/ Polycystic Kidney Diseases - pathology
/ Proteins
/ Transcription Factors - deficiency
/ Transcription Factors - genetics
