Journal Article

Clinical implications of elevated serum interleukin-6 in IgG4-related disease

Ikemune, Manami, Ikeura, Tsukasa, Tsukuda, Satoshi, Ando, Yugo, Uchida, Kazushige, Hori, Yuichi, Masuda, Masataka, Tanigawa, Noboru, Ito, Takashi, Nakamaru, Koh, Okazaki, Kazuichi, Tomiyama, Takashi, Terasawa, Rika, Nishio, Akiyoshi, Tanaka, Toshihiro, Yanagawa, Masato, Yamaguchi, Takashi, Fukui, Toshiro

2020

Overview

Some patients with IgG4-related disease (IgG4-RD) exhibit elevated serum interleukin (IL)-6 with excessive inflammatory reactions or with repeating relapse. To date few reports pertaining to clinical implications of elevated serum IL-6 in IgG4-RD patients have been published. The aims of the current retrospective study were to investigate the clinical implications of elevated serum IL-6 in IgG4-RD patients, and to examine whether IL-6 can predict the activity and/or relapse of the disease. We examined the clinical picture at the onset of 43 patients who were diagnosed with IgG4-RD in our hospital and were able to measure serum IL-6 before steroid treatment. The median level of serum IL-6 was 2.2 pg/mL. There was a significant correlation between IL-6 and C-reactive protein (CRP) level (r = 0.397, p = 0.008), hemoglobin level (r = -0.390, p = 0.010) and albumin level (r = -0.556, p < 0.001). When 43 patients were divided into two groups by using a cut-off IL-6 of 4 pg/mL, the high IL-6 group showed higher age, lower albumin, higher CRP and higher aspartate aminotransferase (AST) (age p = 0.014, albumin p = 0.006, CRP p <0.001, AST p = 0.009). Hepatic swelling and splenomegaly were significantly more prevalent in the high IL-6 group than it was in the low IL-6 group (liver p < 0.001, spleen p = 0.020). Biliary tract involvement tended to admit more in the high IL-6 group (p = 0.060). Serum IL-6 level at the onset of IgG4-RD may be significantly correlated with clinical inflammatory parameters and it may also be associated with involvement of the bile duct, liver, and spleen.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Aged / Albumin / Albumins / Aspartate / Aspartate aminotransferase / Aspartate Aminotransferases - blood / Bile Duct Diseases - diagnostic imaging / Bile Duct Diseases - pathology / Bile ducts / Biliary tract / Biology and Life Sciences / C-reactive protein / C-Reactive Protein - analysis / Cytokines / Databases, Factual / Female / Gastroenterology / Glycosylated hemoglobin / Hemoglobin / Hemoglobins / Hemoglobins - analysis / Hepatology / Humans / Immunoglobulin G / Immunoglobulin G4-Related Disease - pathology / Inflammation / Interleukin 6 / Interleukin-6 - blood / Interleukins / Internal medicine / Laboratories / Liver / Liver Diseases - diagnostic imaging / Liver Diseases - pathology / Male / Medical diagnosis / Medicine / Medicine and Health Sciences / Middle Aged / Patients / Serum Albumin - analysis / Spleen / Splenomegaly / Splenomegaly - diagnosis / Steroids / Tomography, X-Ray Computed