Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer

by Amano, Ryosuke , Ohira, Go , Tanaka, Ryota , Tanaka, Hiroaki , Tanaka, Shogo , Ohira, Masaichi , Eguchi, Shimpei , Yashiro, Masakazu , Kubo, Shoji , Kimura, Kenjiro

in Bile ducts / Biliary tract / Biliary tract diseases / Biliary Tract Neoplasms - pathology / Biliary Tract Neoplasms - surgery / Biology and Life Sciences / Breast cancer / Cancer / Cancer therapies / CD4 antigen / CD8 antigen / CD8-Positive T-Lymphocytes / Chemotherapy / Cholangiocarcinoma / Colorectal cancer / Foxp3 protein / Gallbladder cancer / Gastric cancer / Health aspects / Hepatectomy / Humans / Immune system / Immunotherapy / Lymphocytes / Lymphocytes, Tumor-Infiltrating / Macrophages / Medical prognosis / Medical research / Medicine and Health Sciences / Metastases / Patients / Prognosis / Retrospective Studies / Surgery / Survival / Tumor Microenvironment / Tumor-infiltrating lymphocytes / Tumors

2023

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer

by Amano, Ryosuke , Ohira, Go , Tanaka, Ryota , Tanaka, Hiroaki , Tanaka, Shogo , Ohira, Masaichi , Eguchi, Shimpei , Yashiro, Masakazu , Kubo, Shoji , Kimura, Kenjiro

2023

Confirm

Do you wish to request the book?

Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer

by Amano, Ryosuke , Ohira, Go , Tanaka, Ryota , Tanaka, Hiroaki , Tanaka, Shogo , Ohira, Masaichi , Eguchi, Shimpei , Yashiro, Masakazu , Kubo, Shoji , Kimura, Kenjiro

2023

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Tumor-infiltrating lymphocytes and macrophages as a significant prognostic factor in biliary tract cancer

Amano, Ryosuke,

Ohira, Go,

Tanaka, Ryota,

Tanaka, Hiroaki,

Tanaka, Shogo,

Ohira, Masaichi,

Eguchi, Shimpei,

Yashiro, Masakazu,

Kubo, Shoji,

Kimura, Kenjiro

2023

Overview

The impact of tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) on the prognosis of biliary tract cancer (BTC) is not completely understood. Therefore, in our study, we investigated the effects of the various immune cells infiltration in tumor microenvironment (TME). A total of 130 patients with BTC who underwent surgical treatment at our institution were enrolled in this study. We retrospectively evaluated TILs and TAMs with immunohistochemical staining. With CD8-high, CD4-high, FOXP3-high, and CD68-low in TME as one factor, we calculated Immunoscore according to the number of factors. The high Immunoscore group showed significantly superior overall survival (OS) and recurrence-free survival (RFS) than the low Immunoscore group (median OS, 60.8 vs. 26.4 months, p = 0.001; median RFS not reached vs. 17.2 months, p < 0.001). Also, high Immunoscore was an independent good prognostic factor for OS and RFS (hazards ratio 2.05 and 2.41 and p = 0.01 and p = 0.001, respectively). High Immunoscore group had significantly superior OS and RFS and was an independent good prognostic factor for OS and RFS.

Share this book

Add to My Shelf

Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

Bile ducts

/ Biliary tract

/ Biliary tract diseases

/ Biliary Tract Neoplasms - pathology

/ Biliary Tract Neoplasms - surgery

/ Biology and Life Sciences

/ Breast cancer