Asset Details
Do you wish to reserve the book?
Sleep drive reconfigures wake-promoting clock circuitry to regulate adaptive behavior
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Sleep drive reconfigures wake-promoting clock circuitry to regulate adaptive behavior
Do you wish to request the book?
Sleep drive reconfigures wake-promoting clock circuitry to regulate adaptive behavior
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Sleep drive reconfigures wake-promoting clock circuitry to regulate adaptive behavior
2021
Overview
Circadian rhythms help animals synchronize motivated behaviors to match environmental demands. Recent evidence indicates that clock neurons influence the timing of behavior by differentially altering the activity of a distributed network of downstream neurons. Downstream circuits can be remodeled by Hebbian plasticity, synaptic scaling, and, under some circumstances, activity-dependent addition of cell surface receptors; the role of this receptor respecification phenomena is not well studied. We demonstrate that high sleep pressure quickly reprograms the wake-promoting large ventrolateral clock neurons to express the pigment dispersing factor receptor (PDFR). The addition of this signaling input into the circuit is associated with increased waking and early mating success. The respecification of PDFR in both young and adult large ventrolateral neurons requires 2 dopamine (DA) receptors and activation of the transcriptional regulator nejire (cAMP response element-binding protein [CREBBP]). These data identify receptor respecification as an important mechanism to sculpt circuit function to match sleep levels with demand.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Age
/ Animals
/ Behavior
/ Behavior, Animal - physiology
/ Biological Clocks - physiology
/ Circuits
/ Cyclic AMP response element-binding protein
/ Dopamine
/ Drosophila melanogaster - physiology
/ Drosophila Proteins - metabolism
/ Neurons
/ p300-CBP Transcription Factors - metabolism
/ Receptors, G-Protein-Coupled - metabolism
/ Research and Analysis Methods
/ Sleep
