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Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia

by Urmaliya, Vijay , Winerdal, Malin E. , Fredholm, Bertil B. , Winqvist, Ola , Ådén, Ulrika , Winerdal, Max

in Adenosine / Animals / Animals, Newborn / Biology and Life Sciences / Brain / Brain injury / Caffeine / Caffeine - administration & dosage / Carotid arteries / Disease Models, Animal / Dosage and administration / Dose-Response Relationship, Drug / Drug dosages / Flow cytometry / Head injuries / Health aspects / Humans / Hypoxia / Hypoxia-Ischemia, Brain - drug therapy / Hypoxia-Ischemia, Brain - pathology / Immune response / Immunoglobulins / Immunology / Ischemia / Medicine and Health Sciences / Mice / Neonates / Neurons - drug effects / Neurons - pathology / Neuroprotection / Neuroprotective Agents - administration & dosage / Newborn babies / Newborn infants / Phosphates / Physical Sciences / Physiology / Prevention / Research and Analysis Methods / Rodents / Studies / Traumatic brain injury / Treatment Outcome

2017

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Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia

by Urmaliya, Vijay , Winerdal, Malin E. , Fredholm, Bertil B. , Winqvist, Ola , Ådén, Ulrika , Winerdal, Max

2017

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Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia

by Urmaliya, Vijay , Winerdal, Malin E. , Fredholm, Bertil B. , Winqvist, Ola , Ådén, Ulrika , Winerdal, Max

2017

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Journal Article

Single Dose Caffeine Protects the Neonatal Mouse Brain against Hypoxia Ischemia

Urmaliya, Vijay,

Winerdal, Malin E.,

Fredholm, Bertil B.,

Winqvist, Ola,

Ådén, Ulrika,

Winerdal, Max

2017

Overview

In this randomized blinded study, we investigated caffeine 5 mg/kg treatment given directly after neonatal brain hypoxia ischemia. Brain morphology, behavior and key brain infiltrating immune populations were examined. Caffeine treatment significantly improves outcome when compared to phosphate buffered saline. Flow cytometric analysis of immune responses revealed no persistent immunological alterations. Given its safety caffeine emerges as a candidate for neuroprotective intervention after neonatal brain injury.

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Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

Adenosine

/ Animals

/ Animals, Newborn

/ Biology and Life Sciences

/ Brain

/ Brain injury

/ Caffeine