Journal Article

Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure

Kjær Stampe, Niels, Midgley, Sofie E., Lodder, Elisabeth M., Madsen, Jeppe Ekstrand Halkjær, Gerds, Thomas, Tfelt-Hansen, Jacob, Bezzina, Connie R., Torp-Pedersen, Christian, Engstrøm, Thomas, Tanck, Michael W. T., Al-Hussainy, Nour R., Jabbari, Reza, Ravn Jacobsen, Mia, Glinge, Charlotte, Pedersen, Frants, Køber, Lars, Trebbien, Ramona, Kølsen Fischer, Thea

2020

Overview

To investigate seasonality and association of increased enterovirus and influenza activity in the community with ventricular fibrillation (VF) risk during first ST-elevation myocardial infarction (STEMI). This study comprised all consecutive patients with first STEMI (n = 4,659; aged 18-80 years) admitted to the invasive catheterization laboratory between 2010-2016, at Copenhagen University Hospital, Rigshospitalet, covering eastern Denmark (2.6 million inhabitants, 45% of the Danish population). Hospital admission, prescription, and vital status data were assessed using Danish nationwide registries. We utilized monthly/weekly surveillance data for enterovirus and influenza from the Danish National Microbiology Database (2010-2016) that receives copies of laboratory tests from all Danish departments of clinical microbiology. Of the 4,659 consecutively enrolled STEMI patients, 581 (12%) had VF before primary percutaneous coronary intervention. In a subset (n = 807), we found that VF patients experienced more generalized fatigue and flu-like symptoms within 7 days before STEMI compared with the patients without VF (OR 3.39, 95% CI 1.76-6.54). During the study period, 2,704 individuals were diagnosed with enterovirus and 19,742 with influenza. No significant association between enterovirus and VF (OR 1.00, 95% CI 0.99-1.02), influenza and VF (OR 1.00, 95% CI 1.00-1.00), or week number and VF (p-value 0.94 for enterovirus and 0.89 for influenza) was found. We found no clear seasonality of VF during first STEMI. Even though VF patients had experienced more generalized fatigue and flu-like symptoms within 7 days before STEMI compared with patients without VF, no relationship was found between enterovirus or influenza exposure and occurrence of VF.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Adolescent / Adult / Aged / Aged, 80 and over / Balloon angioplasty / Biology and Life Sciences / Cardiac arrhythmia / Cardiology / Cardiology and Cardiovascular Disease / Catheterization / Clinical Medicine / Clinical microbiology / Denmark / Emergency medical care / Enteroviruses / Epidemics / Epidemiology / Exposure / Fatigue / Female / Fibrillation / Health aspects / Health care / Heart attack / Heart attacks / Hospital admission and discharge / Hospital patients / Hospitals / Humans / Infectious diseases / Influenza / Influenza, Human - epidemiology / Intubation / Ischemia / Kardiologi och kardiovaskulära sjukdomar / Klinisk medicin / Laboratories / Laboratory tests / Male / Medical and Health Sciences / Medical research / Medicin och hälsovetenskap / Medicine and Health Sciences / Microbiology / Middle Aged / Myocardial infarction / Patients / People and Places / Personal identification numbers / Population / Preventive medicine / Registries / Risk Factors / Seasonal variations / ST Elevation Myocardial Infarction - epidemiology / Studies / Ventricle / Ventricular fibrillation / Ventricular Fibrillation - epidemiology / Viral infections / Virus Diseases - epidemiology / Young Adult