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Chronic inflammation in the etiology of disease across the life span
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Chronic inflammation in the etiology of disease across the life span
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Journal Article
Chronic inflammation in the etiology of disease across the life span
2019
Overview
Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.
Systemic chronic inflammation increases with age and is linked to the development of several diseases, as presented in this Perspective.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Aging
/ Autoimmune Diseases - etiology
/ Autoimmune Diseases - physiopathology
/ Behavior
/ Biology
/ Biomedical and Life Sciences
/ Cardiovascular Diseases - etiology
/ Cardiovascular Diseases - physiopathology
/ Chronic Disease - epidemiology
/ Diabetes
/ Diabetes Mellitus - etiology
/ Diabetes Mellitus - physiopathology
/ Etiology
/ Humans
/ Inflammation - complications
/ Inflammation - physiopathology
/ Ischemia
/ Medicine
/ Neurodegenerative Diseases - etiology
/ Neurodegenerative Diseases - physiopathology
/ Non-alcoholic Fatty Liver Disease - etiology
/ Non-alcoholic Fatty Liver Disease - physiopathology
/ Renal Insufficiency, Chronic - etiology
