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Fonofos Exposure and Cancer Incidence in the Agricultural Health Study
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Fonofos Exposure and Cancer Incidence in the Agricultural Health Study
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Journal Article
Fonofos Exposure and Cancer Incidence in the Agricultural Health Study
2006
Overview
Background: The Agricultural Health Study (AHS) is a prospective cohort study of licensed pesticide applicators from Iowa and North Carolina enrolled 1993-1997 and followed for incident cancer through 2002. A previous investigation in this cohort linked exposure to the organophosphate fonofos with incident prostate cancer in subjects with family history of prostate cancer. Objectives: This finding along with findings of associations between organophosphate pesticides and cancer more broadly led to this study of fonofos and risk of any cancers among 45,372 pesticide applicators enrolled in the AHS. Methods: Pesticide exposure and other data were collected using self-administered questionnaires. Poisson regression was used to calculate rate ratios (RRs) and 95% confidence intervals (CIs) while controlling for potential confounders. Results: Relative to the unexposed, leukemia risk was elevated in the highest category of lifetime (RR = 2.24; 95% CI, 0.94-5.34,$p_{trend} = 0.07$) and intensity-weighted exposure-days (RR = 2.67; 95% CI, 1.06-6.70,$p_{trend} = 0.04$), a measure that takes into account factors that modify pesticide exposure. Although prostate cancer risk was unrelated to fonofos use overall, among applicators with a family history of prostate cancer, we observed a significant dose-response trend for lifetime exposure-days ($p_{trend} = 0.02$, RR highest tertile vs. unexposed = 1.77, 95% CI, 1.03-3.05;$RR_{interaction} = 1.28$, 95% CI, 1.07-1.54). Intensity-weighted results were similar. No associations were observed with other examined cancer sites. Conclusions: Further study is warranted to confirm findings with respect to leukemia and determine whether genetic susceptibility modifies prostate cancer risk from pesticide exposure.
Publisher
National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare,National Institute of Environmental Health Sciences
Subject
/ Agricultural Workers' Diseases - chemically induced
/ Agricultural Workers' Diseases - epidemiology
/ Exposure
/ Female
/ Genetics
/ Humans
/ Leukemia
/ Male
/ Neoplasms - chemically induced
/ North Carolina - epidemiology
/ Occupational Exposure - adverse effects
/ Occupational Exposure - analysis
/ Occupational Exposure - statistics & numerical data
/ Organophosphorus Compounds - analysis
/ Organothiophosphorus Compounds - analysis
/ Organothiophosphorus Compounds - poisoning
/ Prostatic Neoplasms - epidemiology
/ Prostatic Neoplasms - etiology
