Journal Article

Personality dimensions of patients can change during the course of parkinson’s disease

Mathilde Boussac, Mathieu Anheim, Alexandre Eusebio, Christine Brefel-Courbon, Anne-Sophie Rolland, Bruno Giordana, Sophie Drapier, Béchir Jarraya, Olivier Rascol, Christophe Arbus, Caroline Moreau, Estelle Harroch, Fabienne Ory-Magne, Jean-Christophe Corvol, A. Marques, Aurélie Croiset, Mélissa Tir, Elodie Hainque, Mylène Meyer, David Maltête, Tiphaine Rouaud, Julia Dupouy, Vanessa Rousseau, Stéphane Thobois, Lhaouas Belamri, Isabelle Benatru, Nicolas Auzou, David Devos

2021

Overview

Studies assessing personality dimensions by the \"Temperament and Character Inventory\" (TCI) have previously found an association between Parkinson's disease (PD) and lower Novelty Seeking and higher Harm Avoidance scores. Here, we aimed to describe personality dimensions of PD patients with motor fluctuations and compare them to a normative population and other PD populations. All PD patients awaiting Deep Brain Stimulation (DBS) answered the TCI before neurosurgery. Their results were compared to those of historical cohorts (a French normative population, a de novo PD population, and a PD population with motor fluctuations). Most personality dimensions of our 333 included PD patients with motor fluctuations who are candidates for DBS were different from those of the normative population and some were also different from those of the De Novo PD population, whereas they were similar to those of another population of PD patients with motor fluctuations. During the course of PD, personality dimensions can change in parallel with the development of motor fluctuations, either due to the evolution of the disease and/or dopaminergic treatments.

• Publisher: Public Library of Science (PLoS),Public Library of Science
• Subject: [SDV]Life Sciences [q-bio] / Aged / Biology and Life Sciences / Character / Cognition & reasoning / Complications and side effects / Deep brain stimulation / Development and progression / Dopamine receptors / Female / Fluctuations / Humans / Life Sciences / Male / Medical imaging / Medical treatment / Medicine / Medicine and Health Sciences / MESH: Aged / MESH: Character / MESH: Female / MESH: Humans / MESH: Male / MESH: Middle Aged / MESH: Parkinson Disease / psychology / MESH: Personality Disorders / psychology / MESH: Personality Inventory / Middle Aged / Movement disorders / Neurodegenerative diseases / Neurology / Neurosciences / Neurosurgery / Parkinson Disease / Parkinson Disease - psychology / Parkinson's disease / Personality / Personality Disorders / Personality Disorders - psychology / Personality Inventory / Pharmacology / Physical Sciences / Population / Psychiatric research / Psychological aspects / Q / Quality of life / R / Science / Social Sciences / Verne, Jules (1828-1905)