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Effect of Obesity on Acute Ozone-Induced Changes in Airway Function, Reactivity, and Inflammation in Adult Females

by Wu, Jihong , Bromberg, Philip A. , Alexis, Neil E. , London, Stephanie J. , Ivins, Sally , Travlos, Gregory , Bennett, William D. , Brar, Sukhdev S.

in Adiponectin / Adolescent / Adult / Air exposure / Airway / Animal models / Biology and Life Sciences / Biomarkers - metabolism / Blood / Body mass / Body mass index / Bronchial Hyperreactivity - chemically induced / Bronchial Hyperreactivity - diagnosis / Bronchial Hyperreactivity - metabolism / C-reactive protein / Case-Control Studies / Causes of / Double-Blind Method / Earth Sciences / Ecology and Environmental Sciences / Exposure / Female / Females / Forced Expiratory Volume / Humans / Inflammation - etiology / Inflammation - metabolism / Inflammation - pathology / Influence / Interleukin 1 / Interleukin 6 / Interleukin 8 / Interleukins / Leptin / Leukocytes (neutrophilic) / Lungs / Medicine and Health Sciences / Methacholine / Obesity / Obesity - complications / Obesity - physiopathology / Ozone / Ozone - adverse effects / Physical Sciences / Physiological aspects / Reactivity / Research and Analysis Methods / Respiratory function / Respiratory System - drug effects / Respiratory tract / Respiratory tract diseases / Rodents / Smoking / Sputum / Tumor necrosis factor-α / Womens health / Young Adult

2016

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Effect of Obesity on Acute Ozone-Induced Changes in Airway Function, Reactivity, and Inflammation in Adult Females

by Wu, Jihong , Bromberg, Philip A. , Alexis, Neil E. , London, Stephanie J. , Ivins, Sally , Travlos, Gregory , Bennett, William D. , Brar, Sukhdev S.

2016

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Effect of Obesity on Acute Ozone-Induced Changes in Airway Function, Reactivity, and Inflammation in Adult Females

by Wu, Jihong , Bromberg, Philip A. , Alexis, Neil E. , London, Stephanie J. , Ivins, Sally , Travlos, Gregory , Bennett, William D. , Brar, Sukhdev S.

2016

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Journal Article

Effect of Obesity on Acute Ozone-Induced Changes in Airway Function, Reactivity, and Inflammation in Adult Females

Wu, Jihong,

Bromberg, Philip A.,

Alexis, Neil E.,

London, Stephanie J.,

Ivins, Sally,

Travlos, Gregory,

Bennett, William D.,

Brar, Sukhdev S.

2016

Overview

We previously observed greater ozone-induced lung function decrements in obese than non-obese women. Animal models suggest that obesity enhances ozone-induced airway reactivity and inflammation. In a controlled exposure study, we compared the acute effect of randomized 0.4ppm ozone and air exposures (2 h with intermittent light exercise) in obese (N = 20) (30

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Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

/ Adult

/ Airway

/ Biology and Life Sciences