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Regulation of a Neuronal Form of Focal Adhesion Kinase by Anandamide
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Regulation of a Neuronal Form of Focal Adhesion Kinase by Anandamide
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Journal Article
Regulation of a Neuronal Form of Focal Adhesion Kinase by Anandamide
1996
Overview
Anandamide is an endogenous ligand for central cannabinoid receptors and is released after neuronal depolarization. Anandamide increased protein tyrosine phosphorylation in rat hippocampal slices and neurons in culture. The action of anandamide resulted from the inhibition of adenylyl cyclase and cyclic adenosine 3′,5′-monophosphate-dependent protein kinase. One of the proteins phosphorylated in response to anandamide was an isoform of pp125-focal adhesion kinase (FAK+) expressed preferentially in neurons. Focal adhesion kinase is a tyrosine kinase involved in the interactions between the integrins and actin-based cytoskeleton. Thus, anandamide may exert neurotrophic effects and play a role in synaptic plasticity.
Publisher
American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science,American Association for the Advancement of Science (AAAS)
Subject
/ Adenylyl Cyclases - metabolism
/ Animals
/ Arachidonic Acid - pharmacology
/ Arachidonic Acids - pharmacology
/ Biochemistry, Molecular Biology
/ Biological and medical sciences
/ Brain
/ Cell Adhesion Molecules - metabolism
/ Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors
/ Cyclic AMP-Dependent Protein Kinases - metabolism
/ Focal Adhesion Protein-Tyrosine Kinases
/ Fundamental and applied biological sciences. Psychology
/ Neuronal Plasticity - drug effects
/ Neurons
/ Phosphotyrosine - metabolism
/ Protein-Tyrosine Kinases - metabolism
/ Rats
/ Receptors, Drug - metabolism
/ Rodents
