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PER protein interactions and temperature compensation of a circadian clock in Drosophila
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PER protein interactions and temperature compensation of a circadian clock in Drosophila
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PER protein interactions and temperature compensation of a circadian clock in Drosophila
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Journal Article
PER protein interactions and temperature compensation of a circadian clock in Drosophila
1995
Overview
The periods of circadian clocks are relatively temperature-insensitive. Indeed, the perL mutation in the Drosophila melanogaster period gene, a central component of the clock, affects temperature compensation as well as period length. The per protein (PER) contains a dimerization domain (PAS) within which the perL mutation is located. Amino acid substitutions at the perL position rendered PER dimerization temperature-sensitive. In addition, another region of PER interacted with PAS, and the perL mutation enhanced this putative intramolecular interaction, which may compete with PAS-PAS intermolecular interactions. Therefore, temperature compensation of circadian period in Drosophila may be due in part to temperature-independent PER activity, which is based on competition between inter- and intramolecular interactions with similar temperature coefficients.
Publisher
American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Animals
/ Biochemistry. Physiology. Immunology
/ Biological and medical sciences
/ Climate
/ Dimers
/ Drosophila melanogaster - genetics
/ Drosophila melanogaster - physiology
/ Fundamental and applied biological sciences. Psychology
/ genetics
/ Insecta
/ Insects
/ Mutation
/ Nuclear Proteins - chemistry
/ Nuclear Proteins - metabolism
/ Plasmids
/ Proteins
/ Yeasts
