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Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli
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Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli
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Journal Article
Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli
2001
Overview
The macrocyclic core of the antibiotic erythromycin, 6-deoxyerythronolide B (6dEB), is a complex natural product synthesized by the soil bacterium Saccharopolyspora erythraea through the action of a multifunctional polyketide synthase (PKS). The engineering potential of modular PKSs is hampered by the limited capabilities for molecular biological manipulation of organisms (principally actinomycetes) in which complex polyketides have thus far been produced. To address this problem, a derivative of Escherichia coli has been genetically engineered. The resulting cellular catalyst converts exogenous propionate into 6dEB with a specific productivity that compares well with a high-producing mutant of S. erythraea that has been incrementally enhanced over decades for the industrial production of erythromycin.
Publisher
American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Acyl Coenzyme A - metabolism
/ Bacteria
/ Biological and medical sciences
/ Biology of microorganisms of confirmed or potential industrial interest
/ Climate
/ E coli
/ Erythromycin - analogs & derivatives
/ Escherichia coli - enzymology
/ Fundamental and applied biological sciences. Psychology
/ Genes
/ Multienzyme Complexes - genetics
/ Multienzyme Complexes - metabolism
/ Mutation
/ Plasmids
/ Recombinant Fusion Proteins - metabolism
/ Saccharopolyspora - enzymology
/ Saccharopolyspora - genetics
/ Transferases (Other Substituted Phosphate Groups) - genetics
/ Transferases (Other Substituted Phosphate Groups) - metabolism
