Asset Details
Do you wish to reserve the book?
A Role for Thrombin Receptor Signaling in Endothelial Cells during Embryonic Development
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
A Role for Thrombin Receptor Signaling in Endothelial Cells during Embryonic Development
Do you wish to request the book?
A Role for Thrombin Receptor Signaling in Endothelial Cells during Embryonic Development
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
A Role for Thrombin Receptor Signaling in Endothelial Cells during Embryonic Development
2001
Overview
The coagulation protease thrombin triggers fibrin formation, platelet activation, and other cellular responses at sites of tissue injury. We report a role for PAR1, a protease-activated G protein-coupled receptor for thrombin, in embryonic development. Approximately half of Par1-/-mouse embryos died at midgestation with bleeding from multiple sites. PAR1 is expressed in endothelial cells, and a PAR1 transgene driven by an endothelial-specific promoter prevented death of Par1-/-embryos. Our results suggest that the coagulation cascade and PAR1 modulate endothelial cell function in developing blood vessels and that thrombin's actions on endothelial cells-rather than on platelets, mesenchymal cells, or fibrinogen-contribute to vascular development and hemostasis in the mouse embryo.
Publisher
American Society for the Advancement of Science,American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Animals
/ Biological and medical sciences
/ Bleeding
/ Blood
/ Blood Coagulation Factors - physiology
/ Embryology: invertebrates and vertebrates. Teratology
/ Embryonic and Fetal Development
/ Embryos
/ Endothelium, Vascular - cytology
/ Endothelium, Vascular - embryology
/ Endothelium, Vascular - metabolism
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Injuries
/ Male
/ Mice
/ Neovascularization, Physiologic
/ Organogenesis. Physiological fonctions
/ Proteins
/ Receptors, Thrombin - deficiency
/ Receptors, Thrombin - genetics
/ Receptors, Thrombin - physiology
/ Thrombin
/ Tissues
/ Yolk sac
