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β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury

by Poschmann, Jeremie , Sadek, Abderrahmane , Jurado, Leonardo F , Sadeghi, Mina , Divangahi, Maziar , Pernet, Erwan , Kristof, Arnold S , Moumni, Mohieddine , Lapshina, Elizabeth , Tran, Kim A , Prevel, Renaud

in acute lung injury / Animal models / Animals / beta-Glucans - administration & dosage / beta-Glucans - metabolism / Bone marrow / Chemokines / Cytokines / Disease Models, Animal / Epigenetics / Hematopoietic stem cells / Histology / Immunity / Immunity (Disease) / Immunological memory / Immunology and Inflammation / Inflammation / Interferon-gamma - metabolism / Lavage / Lectins, C-Type / Leukocytes (neutrophilic) / Life Sciences / Ligands / Lipopolysaccharides / Lung Injury - immunology / Lung Injury - pathology / Lungs / Macrophages / Macrophages, Alveolar - drug effects / Macrophages, Alveolar - immunology / Metabolism / Mice / Mice, Inbred C57BL / Neutrophils / Neutrophils - drug effects / Neutrophils - immunology / Neutrophils - metabolism / Permeability / Polyinosinic:polycytidylic acid / Sepsis / trained immunity / Tumor necrosis factor-TNF / β-Glucan / γ-Interferon

2025

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β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury

2025

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β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury

2025

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Journal Article

β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury

Poschmann, Jeremie,

Sadek, Abderrahmane,

Jurado, Leonardo F,

Sadeghi, Mina,

Divangahi, Maziar,

Pernet, Erwan,

Kristof, Arnold S,

Moumni, Mohieddine,

Lapshina, Elizabeth,

Tran, Kim A,

Prevel, Renaud

2025

Overview

Alveolar macrophages (AMs) reside in the lower airways and play a crucial role in lung health and response to sterile inflammation and infections. AMs possess remarkable adaptability to different environmental challenges that can persist through their memory capacity (trained immunity). β-Glucan has been characterized as a potent inducer of central trained immunity by reprogramming haematopoietic stem cells in the bone marrow. In the present study, we show that systemic administration of β-glucan in mice induces peripheral trained immunity by reprogramming AMs in the lungs, in a Dectin1-independent manner. We furthermore demonstrate that AM reprogramming at both the transcriptional and metabolic levels exacerbate lung injury following bacterial (lipopolysaccharide) or viral (polyI:C) challenges via a neutrophil/IFN-γ-dependent manner. These findings identify an additional facet of β-glucan in trained immunity involving AM reprogramming and shed light on the potential detrimental effects of trained immunity.

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Publisher

eLife Sciences Publications Ltd,eLife Sciences Publication,eLife Sciences Publications, Ltd

Subject

acute lung injury

/ Animal models

/ Animals

/ beta-Glucans - administration & dosage

/ beta-Glucans - metabolism

/ Bone marrow

/ Chemokines