Asset Details
Do you wish to reserve the book?
Targeting of AKT/ERK/CTNNB1 by DAW22 as a potential therapeutic compound for malignant peripheral nerve sheath tumor
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Targeting of AKT/ERK/CTNNB1 by DAW22 as a potential therapeutic compound for malignant peripheral nerve sheath tumor
Do you wish to request the book?
Targeting of AKT/ERK/CTNNB1 by DAW22 as a potential therapeutic compound for malignant peripheral nerve sheath tumor
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Targeting of AKT/ERK/CTNNB1 by DAW22 as a potential therapeutic compound for malignant peripheral nerve sheath tumor
2018
Overview
Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive form of soft tissue neoplasm with extremely poor prognosis and no effective medical options currently available. MPNSTs can occur either sporadically or in association with the neurofibromatosis type 1 (NF1) syndrome. Importantly, activation of RAS/RAF/MEK/ERK, PI3K/AKT/mTOR, and WNT/CTNNB1 signaling pathways has been reported in both NF1‐related and late‐stage sporadic MPNSTs. In this study, we found that DAW22, a natural sesquiterpene coumarin compound isolated from Ferula ferulaeoides (Steud.) Korov., could inhibit cell proliferation and colony formation in five established human MPNST cancer cell lines. Further molecular mechanism exploration indicated that DAW22 could target the main components in the MPNST tumorigenic pathways: namely suppress phosphorylation of AKT and ERK, and reduce levels of non‐phospho (active) CTNNB1. Using the xenograft mouse model transplanted with human MPNST cancer cell line, daily treatment with DAW22 for 25 days was effective in reducing tumor growth. These results support DAW22 as an alternative therapeutic compound for MPNST treatment by affecting multiple signaling transduction pathways in its disease progression. In this study, we evaluated the anti‐tumor effect of natural compound DAW22 on malignant peripheral nerve sheath tumors (MPNSTs) using both in vitro and in vivo approaches. The anti‐tumor effect was caused by the induction of apoptosis and targeting of AKT, ERK, and CTNNB1 signaling pathways. These results support DAW22 as an alternative therapeutic compound for MPNST treatment by affecting multiple signaling transduction pathways in its disease progression.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
Subject
1-Phosphatidylinositol 3-kinase
/ AKT
/ Animals
/ Antineoplastic Agents, Phytogenic - chemistry
/ Antineoplastic Agents, Phytogenic - pharmacology
/ Cell Proliferation - drug effects
/ Coumarin
/ DAW22
/ ERK
/ Extracellular signal-regulated kinase
/ Kinases
/ Mice
/ MPNST
/ Mutation
/ Nerve Sheath Neoplasms - drug therapy
/ Nerve Sheath Neoplasms - metabolism
/ Nerve Sheath Neoplasms - pathology
/ Phosphatidylinositol 3-Kinases - metabolism
/ Proteins
/ Proto-Oncogene Proteins c-akt - metabolism
/ Sesquiterpenes - pharmacology
/ Signal Transduction - drug effects
/ Tumors
