Asset Details
Do you wish to reserve the book?
Quasispecies theory and the behavior of RNA viruses
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Quasispecies theory and the behavior of RNA viruses
Do you wish to request the book?
Quasispecies theory and the behavior of RNA viruses
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Quasispecies theory and the behavior of RNA viruses
2010
Overview
A large number of medically important viruses, including HIV, hepatitis C virus, and influenza, have RNA genomes. These viruses replicate with extremely high mutation rates and exhibit significant genetic diversity. This diversity allows a viral population to rapidly adapt to dynamic environments and evolve resistance to vaccines and antiviral drugs. For the last 30 years, quasispecies theory has provided a population-based framework for understanding RNA viral evolution. A quasispecies is a cloud of diverse variants that are genetically linked through mutation, interact cooperatively on a functional level, and collectively contribute to the characteristics of the population. Many predictions of quasispecies theory run counter to traditional views of microbial behavior and evolution and have profound implications for our understanding of viral disease. Here, we discuss basic principles of quasispecies theory and describe its relevance for our understanding of viral fitness, virulence, and antiviral therapeutic strategy.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Disease
/ Genomes
/ Human immunodeficiency virus
/ Identification and classification
/ Methods
/ Mutation
/ Review
/ Theory
/ Vaccines
/ Virology/Antivirals, including Modes of Action and Resistance
/ Virology/Effects of Virus Infection on Host Gene Expression
/ Virology/Emerging Viral Diseases
/ Virology/New Therapies, including Antivirals and Immunotherapy
/ Virology/Virus Evolution and Symbiosis
/ Viruses
We currently cannot retrieve any items related to this title. Kindly check back at a later time.