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Prognostic Significance of CD30 in Transformed Mycosis Fungoides: A Systematic Review and Meta-Analysis
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Prognostic Significance of CD30 in Transformed Mycosis Fungoides: A Systematic Review and Meta-Analysis
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Journal Article
Prognostic Significance of CD30 in Transformed Mycosis Fungoides: A Systematic Review and Meta-Analysis
2021
Overview
Objectives: Several studies suggested that CD30 expression is a favorable prognostic marker in transformed mycosis fungoides (tMF). However, evidence in this field is still unclear. This systematic review and meta-analysis aimed to evaluate the prognostic significance of CD30 in tMF. Methods: Electronic databases were searched from their inception to June 2020 for all studies assessing the prognostic value of CD30 in tMF. Pooled hazard ratio (HR) for death was calculated; a P value less than.05 was considered significant. Inconsistency index (I2) was used to assess statistical heterogeneity among studies. Results: Seven studies with 323 patients were included. CD30 expression in tMF was significantly associated with a decreased hazard of death both on univariate (HR, 0.459; 95% confidence interval [CI], 0.319- 0.660; P <.001) and multivariate analysis (HR, 0.503; 95% CI, 0.345-0.734; P <.001), and the statistical heterogeneity among studies was null in all analyses ([I.sup.2] = 0%). Conclusions: tMF cases with CD30 expression in large cells have a hazard of death two times lower than CD30-negative cases. Key Words: CD30; Cutaneous lymphoma; Mycosis fungoides; Prognosis; Transformation
Publisher
Oxford University Press
Subject
