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Evidence for Influenza Virus CNS Invasion Along the Olfactory Route in an Immunocompromised Infant

by van Riel, Debby , Kuiken, Thijs , GeurtsvanKessel, Corine , van der Vries, Erhard , Osterhaus, Ab D. M. E. , van Rossum, Annemarie M.C. , Leijten, Lonneke M. , Verdijk, Rob M.

in Central nervous system / Central Nervous System Infections - virology / Fatal Outcome / Female / H3N2 subtype influenza A virus / H5N1 subtype influenza A virus / Humans / Immunocompromised Host / Infant / Infections / Influenza A virus - classification / Influenza A virus - isolation & purification / Influenza A virus - physiology / Influenza virus / Influenza, Human - immunology / Influenza, Human - virology / Nose / Olfactory bulb / Olfactory Bulb - virology / Orthomyxoviridae / Orthomyxoviridae - physiology / Pancytopenia / Pandemics / Parkinson disease / Viruses

2014

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Evidence for Influenza Virus CNS Invasion Along the Olfactory Route in an Immunocompromised Infant

by van Riel, Debby , Kuiken, Thijs , GeurtsvanKessel, Corine , van der Vries, Erhard , Osterhaus, Ab D. M. E. , van Rossum, Annemarie M.C. , Leijten, Lonneke M. , Verdijk, Rob M.

2014

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Evidence for Influenza Virus CNS Invasion Along the Olfactory Route in an Immunocompromised Infant

by van Riel, Debby , Kuiken, Thijs , GeurtsvanKessel, Corine , van der Vries, Erhard , Osterhaus, Ab D. M. E. , van Rossum, Annemarie M.C. , Leijten, Lonneke M. , Verdijk, Rob M.

2014

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Journal Article

Evidence for Influenza Virus CNS Invasion Along the Olfactory Route in an Immunocompromised Infant

van Riel, Debby,

Kuiken, Thijs,

GeurtsvanKessel, Corine,

van der Vries, Erhard,

Osterhaus, Ab D. M. E.,

van Rossum, Annemarie M.C.,

Leijten, Lonneke M.,

Verdijk, Rob M.

2014

Overview

Central nervous system (CNS) disease is the most common extrarespiratory complication of influenza in humans. However, the pathogenesis, including the route of virus entry, is largely unknown. Here we present, for the first time, evidence of influenza virus entry into the CNS via the olfactory route in an immune-compromised infant. Since the nasal cavity is a primary site of influenza virus replication and is directly connected to the CNS via the olfactory nerve, these results imply that influenza virus invasion of the CNS may occur more often than previously believed.

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Publisher

Oxford University Press

Subject

Central nervous system

/ Central Nervous System Infections - virology

/ Fatal Outcome

/ Female

/ H3N2 subtype influenza A virus

/ H5N1 subtype influenza A virus

/ Humans