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Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination
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Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination
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Journal Article
Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination
2021
Overview
This report describes a very rare but life-threatening sequela of vaccination with ChAdOx1 nCoV-19. Within 10 days after a first injection, five health care workers presented with thrombocytopenia and thromboses, including cerebral venous sinus thrombosis with catastrophic outcome. The apparent cause is an anti-PF4 antibody capable of platelet activation; intravenous immune globulin may be therapeutic.
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Autoimmune Diseases - etiology
/ Consent
/ COVID-19
/ COVID-19 Vaccines - adverse effects
/ Edema
/ Enzyme-Linked Immunosorbent Assay
/ Female
/ Heparin
/ Humans
/ Male
/ Original
/ Platelet Factor 4 - immunology
/ Proteins
/ Severe acute respiratory syndrome coronavirus 2
/ Sinuses
/ Stroke
/ Vaccines
