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Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women

by Landovitz, Raphael J , Marrazzo, Jeanne , Anderson, Peter , Holtz, Timothy H , Bryan, Marcus , Overton, Edgar T , Rooney, James F , Rinehart, Alex , Losso, Marcelo H , Blanchette, Cheryl , Cottle, Leslie , Chariyalertsak, Suwat , Phanuphak, Nittaya , Smith, Kimberly Y , Valencia Huamaní, Javier , Richardson, Paul , Sista, Nirupama D , Hanscom, Brett , Marzinke, Mark , Asmelash, Aida , Coelho, Lara , Cabello, Robinson , Gallardo-Cartagena, Jorge A , Scott, Hyman , Fields, Sheldon D , Hinojosa, Juan C , Tran, Ha V , Sugarman, Jeremy , Santos, Breno , Middelkoop, Keren , Kelley, Colleen F , Dunne, Eileen F , Madruga, J. Valdez , Hendrix, Craig , Safren, Steven , Kofron, Ryan M , Li, Maoji , Eshleman, Susan H , Psaros, Christina , Gomez-Feliciano, Kailazarid , Donnell, Deborah , Sued, Omar , McCauley, Marybeth , Wang, Zhe , Shin, Katherine , Margolis, David , Gonzales, Pedro , Clement, Meredith E , Sullivan, Philip , Kallas, Esper G , Swaminathan, Shobha , Piwowar-Manning, Estelle , Gaur, Aditya H , Daar, Eric , del Rio, Carlos , Spreen, William , Lucas, Jonathan , Brown, Todd T , Frank, Ian , Cohen, Myron S , Jennings, Andrea , Gulick, Roy M , Adeyeye, Adeola , Grinsztejn,

in Acquired immune deficiency syndrome / Administration, Oral / Adult / Aged / AIDS / Allergies / Anti-HIV Agents - therapeutic use / Antigens / Antiretroviral drugs / Cisgender / Delayed-Action Preparations - administration & dosage / Disease prevention / Dosage / Double-Blind Method / Double-blind studies / Drug Administration Schedule / Drug dosages / Drug Resistance - genetics / Emtricitabine / Female / Gays & lesbians / Global Health / Hepatitis / HIV / HIV Infections - prevention & control / HIV Integrase Inhibitors - administration & dosage / HIV Integrase Inhibitors - adverse effects / Homosexuality, Male / Human immunodeficiency virus / Humans / Infections / Infectious Disease / Infectious diseases / Injections, Intramuscular - adverse effects / Integrase / Intention to Treat Analysis / Laboratories / Male / Medication Adherence / Mens health / Middle Aged / Plasma / Pre-Exposure Prophylaxis / Prophylaxis / Pyridones - administration & dosage / Pyridones - adverse effects / Tenofovir / Tenofovir - therapeutic use / Transgender Persons / Womens health / Young Adult

2021

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2021

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2021

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Journal Article

Cabotegravir for HIV Prevention in Cisgender Men and Transgender Women

Landovitz, Raphael J,

Marrazzo, Jeanne,

Anderson, Peter,

Holtz, Timothy H,

Bryan, Marcus,

Overton, Edgar T,

Rooney, James F,

Rinehart, Alex,

Losso, Marcelo H,

Blanchette, Cheryl,

Cottle, Leslie,

Chariyalertsak, Suwat,

Phanuphak, Nittaya,

Smith, Kimberly Y,

Valencia Huamaní, Javier,

Richardson, Paul,

Sista, Nirupama D,

Hanscom, Brett,

Marzinke, Mark,

Asmelash, Aida,

Coelho, Lara,

Cabello, Robinson,

Gallardo-Cartagena, Jorge A,

Scott, Hyman,

Fields, Sheldon D,

Hinojosa, Juan C,

Tran, Ha V,

Sugarman, Jeremy,

Santos, Breno,

Middelkoop, Keren,

Kelley, Colleen F,

Dunne, Eileen F,

Madruga, J. Valdez,

Hendrix, Craig,

Safren, Steven,

Kofron, Ryan M,

Li, Maoji,

Eshleman, Susan H,

Psaros, Christina,

Gomez-Feliciano, Kailazarid,

Donnell, Deborah,

Sued, Omar,

McCauley, Marybeth,

Wang, Zhe,

Shin, Katherine,

Margolis, David,

Gonzales, Pedro,

Clement, Meredith E,

Sullivan, Philip,

Kallas, Esper G,

Swaminathan, Shobha,

Piwowar-Manning, Estelle,

Gaur, Aditya H,

Daar, Eric,

del Rio, Carlos,

Spreen, William,

Lucas, Jonathan,

Brown, Todd T,

Frank, Ian,

Cohen, Myron S,

Jennings, Andrea,

Gulick, Roy M,

Adeyeye, Adeola,

Grinsztejn,

2021

Overview

Antiviral medication has emerged as an important tool in the prevention of HIV infection. In this randomized, controlled trial, an injectable long-acting agent, cabotegravir, was found to be superior to daily oral tenofovir disoproxil fumarate–emtricitabine in preventing incident HIV infection in cisgender men and transgender women who have sex with men.

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Publisher

Massachusetts Medical Society

Subject

Acquired immune deficiency syndrome

/ Administration, Oral

/ Adult

/ Aged

/ AIDS

/ Allergies

/ Anti-HIV Agents - therapeutic use