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Multisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes

by Heidemann, Sabrina M , Coates, Bria M , Yager, Phoebe H , Hobbs, Charlotte V , Irby, Katherine , Keenaghan, Michael A , Cvijanovich, Natalie Z , Singh, Aalok R , Hall, Mark W , Smith, Lincoln S , Feldstein, Leora R , Loftis, Laura L , Tarquinio, Keiko M , Schwartz, Stephanie P , Schuster, Jennifer E , Mack, Elizabeth H , Murray, Nancy , Doymaz, Sule , Newburger, Jane W , Maddux, Aline B , Montgomery, Vicki L , Randolph, Adrienne G , Giuliano, John S , Hume, Janet R , Babbitt, Christopher J , Carroll, Christopher L , Halasa, Natasha B , Horwitz, Steven M , Clouser, Katharine N , Rose, Charles E , Patel, Manish M , Riggs, Becky J , Newhams, Margaret M , Friedman, Kevin , Bradford, Tamara T , Soma, Vijaya L , Maamari, Mia , Kong, Michele , Son, Mary Beth F , Fitzgerald, Julie C , Young, Cameron C , Rowan, Courtney M , McLaughlin, Gwenn E

in Adolescent / Allergy / Aneurysms / Biological products / Body temperature / Cardiovascular diseases / Child / Child, Preschool / Childhood Diseases / Children / Cohort Studies / Combined Modality Therapy / Coronary vessels / Coronavirus / Coronaviruses / COVID-19 / COVID-19 - complications / COVID-19 - drug therapy / COVID-19 - immunology / COVID-19 - mortality / Cytokines / Disease control / Drug Therapy, Combination / Female / Fever / Globulins / Glucocorticoids / Glucocorticoids - therapeutic use / Health surveillance / Heart / Hospitalization / Humans / Immunoglobulins / Immunoglobulins, Intravenous - therapeutic use / Immunology / Immunology General / Immunomodulation / Infant / Infectious Disease / Inflammation / Intravenous administration / Length of stay / Logistic Models / Male / Medical laboratories / Multisystem inflammatory syndrome in children / Myocarditis / Patients / Pediatrics / Pediatrics General / Propensity Score / Public Health Surveillance / Severe acute respiratory syndrome coronavirus 2 / Shock - etiology / Shock - prevention & control / Software / Systemic Inflammatory Response Syndrome - complications / Systemic Inflammatory Response Syndrome - drug therapy / Systemic Inflammatory Response Syndrome - immunology / Systemic Inflammatory Response Syndrome - mortality / Treatment Outcome / Veins & arteries / Ventricle / Ventricular Dysfunction, Left - etiology / Ventricular Dysfunction, Left - prevention & control / Young Adult

2021

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2021

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2021

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Journal Article

Multisystem Inflammatory Syndrome in Children — Initial Therapy and Outcomes

Heidemann, Sabrina M,

Coates, Bria M,

Yager, Phoebe H,

Hobbs, Charlotte V,

Irby, Katherine,

Keenaghan, Michael A,

Cvijanovich, Natalie Z,

Singh, Aalok R,

Hall, Mark W,

Smith, Lincoln S,

Feldstein, Leora R,

Loftis, Laura L,

Tarquinio, Keiko M,

Schwartz, Stephanie P,

Schuster, Jennifer E,

Mack, Elizabeth H,

Murray, Nancy,

Doymaz, Sule,

Newburger, Jane W,

Maddux, Aline B,

Montgomery, Vicki L,

Randolph, Adrienne G,

Giuliano, John S,

Hume, Janet R,

Babbitt, Christopher J,

Carroll, Christopher L,

Halasa, Natasha B,

Horwitz, Steven M,

Clouser, Katharine N,

Rose, Charles E,

Patel, Manish M,

Riggs, Becky J,

Newhams, Margaret M,

Friedman, Kevin,

Bradford, Tamara T,

Soma, Vijaya L,

Maamari, Mia,

Kong, Michele,

Son, Mary Beth F,

Fitzgerald, Julie C,

Young, Cameron C,

Rowan, Courtney M,

McLaughlin, Gwenn E

2021

Overview

An analysis of surveillance data on inpatients younger than 21 years of age who had multisystem inflammatory syndrome in children and were hospitalized between March 15 and October 31, 2020, showed that initial treatment with IVIG plus glucocorticoids was associated with a lower risk of cardiovascular dysfunction and a lower incidence of adjunctive therapy use than IVIG alone.

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Publisher

Massachusetts Medical Society

Subject

Adolescent

/ Allergy

/ Aneurysms

/ Biological products

/ Body temperature

/ Cardiovascular diseases

/ Child