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Everolimus-Eluting Stents or Bypass Surgery for Left Main Coronary Artery Disease

by Brown, W. Morris , Schampaert, Erick , Banning, Adrian , Pomar, José , Kandzari, David E , Ungi, Imre , Kosmidou, Ioanna , Horkay, Ferenc , Taggart, David P , Noiseux, Nicolas , Bochenek, Andrzej , Puskas, John , Pagé, Pierre , Mansour, Samer , Bogáts, Gabor , Merkely, Béla , Dressler, Ovidiu , Buszman, Pawel , Morice, Marie-Claude , Lembo, Nicholas , Simonton, Charles A , Pocock, Stuart J , Stone, Gregg W , Gershlick, Anthony , Généreux, Philippe , Kappetein, A. Pieter , Boonstra, Piet W , van Boven, Ad J , Hickey, Mark , Sabaté, Manel , Sabik, Joseph F , Serruys, Patrick W , Mehran, Roxana

in Aged / Cardiovascular disease / Cerebral infarction / Chromium / Clinical trials / Cobalt / Coronary artery / Coronary Artery Bypass - adverse effects / Coronary Artery Disease - mortality / Coronary Artery Disease - surgery / Coronary Artery Disease - therapy / Coronary vessels / Death / Drug delivery / Drug-Eluting Stents / Everolimus - administration & dosage / Female / Heart diseases / Heart surgery / Humans / Implants / Inhibitor drugs / Ischemia / Kaplan-Meier Estimate / Male / Middle Aged / Myocardial infarction / Percutaneous Coronary Intervention - adverse effects / Stents

2016

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2016

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2016

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Journal Article

Everolimus-Eluting Stents or Bypass Surgery for Left Main Coronary Artery Disease

Brown, W. Morris,

Schampaert, Erick,

Banning, Adrian,

Pomar, José,

Kandzari, David E,

Ungi, Imre,

Kosmidou, Ioanna,

Horkay, Ferenc,

Taggart, David P,

Noiseux, Nicolas,

Bochenek, Andrzej,

Puskas, John,

Pagé, Pierre,

Mansour, Samer,

Bogáts, Gabor,

Merkely, Béla,

Dressler, Ovidiu,

Buszman, Pawel,

Morice, Marie-Claude,

Lembo, Nicholas,

Simonton, Charles A,

Pocock, Stuart J,

Stone, Gregg W,

Gershlick, Anthony,

Généreux, Philippe,

Kappetein, A. Pieter,

Boonstra, Piet W,

van Boven, Ad J,

Hickey, Mark,

Sabaté, Manel,

Sabik, Joseph F,

Serruys, Patrick W,

Mehran, Roxana

2016

Overview

In a randomized trial, over 1900 patients with left main coronary artery disease were assigned to percutaneous coronary intervention or coronary-artery bypass grafting. At 3 years, PCI was noninferior to CABG with respect to the rate of death, stroke, or myocardial infarction. Left main coronary artery disease is associated with high morbidity and mortality owing to the large amount of myocardium at risk. European and U.S. guidelines recommend that most patients with left main coronary artery disease undergo coronary-artery bypass grafting (CABG). 1 , 2 Randomized trials have suggested that percutaneous coronary intervention (PCI) with drug-eluting stents might be an acceptable alternative for selected patients with left main coronary disease. 3 – 5 Specifically, in the subgroup of patients with left main coronary disease in the Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) trial, the rate of a composite of death, stroke, myocardial infarction, . . .

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Publisher

Massachusetts Medical Society

Subject

Aged

/ Cardiovascular disease

/ Cerebral infarction

/ Chromium

/ Clinical trials

/ Cobalt

/ Coronary artery