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Tissues, not blood, are where immune cells act
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Journal Article
Tissues, not blood, are where immune cells act
2021
Overview
By contrast, the corresponding blood samples were low in T cells, but high in other immune cells called monocytes, which were displaying unusual patterns of cell-surface receptors. Mouse studies have also shown that, for site-specific viruses such as influenza or human papillomavirus, immunological memory is maintained by dedicated sets of memory T cells at the relevant site. After clinical teams obtain the person's organs for transplantation, our surgeon collects tissues for research - including the intestines, lungs, many lymph nodes, the thymus, spleen, bone marrow, skin, tonsils and salivary glands - and brings everything directly back to the laboratory for processing and sample storage. Technological advances mean that RNA transcripts, protein content and gene modifications can be pinpointed even for single cells.
