Journal Article

Clinical Efficacy of Sodium Cantharidate Vitamin B6 Combined with Concurrent Chemoradiotherapy in the Treatment of Local Advanced Cervical Cancer and its Influence on Tumor Markers

Lu, Dongfang, Mu, Yanmin, Chen, Xiaolin, Zhang, Ling, Guo, Jing

2024

Overview

To explore the clinical efficacy of sodium cantharidate vitamin B6 combined with concurrent chemoradiotherapy in the treatment of local advanced cervical cancer and its influence on tumor markers. A total of 120 patients with locally advanced cervical cancer were enrolled at our hospital from January 2021 to December 2022, and these cases were randomly divided into two groups using a random number table method. The control group was treated with concurrent chemoradiotherapy, while the study group was treated with sodium cantharidate vitamin B6 on the basis of the control group. The clinical efficacy, changes in self-immune function (CD3+, CD4+, CD4+/CD8+ cells ratio), tumor marker levels [Squamous Cell Carcinoma Antigen (SCCA), Carbohydrate Antigen 125 (CA125), Carcinoembryonic Antigen (CEA)], quality of life (Nottingham Health Profile questionnaire), and incidence of adverse events were compared between the two groups. After treatment, there was no significant difference in the overall efficacy and disease control rates between the two groups (P > .05). Before treatment, there was no difference in auto-immune function between the two groups (P > .05). However, after treatment, the study group showed a significant improvement in auto-immune function, and when compared to the control group, the levels of CD3+, CD4+ cells, and the ratio of CD4+/CD8+ cells were higher in the study group (P < .05). Before treatment, there was no difference in tumor markers between the two groups (P > .05). While after treatment, tumor markers in both groups decreased significantly, and in comparison to the control group, the levels of SCCA, CA125, and CEA in the study group were lower (P < .05). Before treatment, there was no significant difference in the quality of life between the two groups (P > .05). However, after treatment, the quality of life in both groups improved, and the study group had a higher quality of life score than the control group (P < .05). There was no significant difference in thrombocytopenia between the two groups (P > .05). The total incidence of leukopenia, neutropenia, and radio-chemotherapy-related gastroenteritis in the study group was lower than that in the control group (P < .05). Sodium cantharidate vitamin B6 combined with concurrent chemoradiotherapy in the treatment of local advanced cervical cancer can not only effectively enhance the autoimmune function, downregulate the level of tumor markers, and improve the quality of patient life, but also cause relatively few adverse reactions.

• Publisher: InnoVision Health Media, Inc
• Subject: Adult / Aged / Antigens / Antigens, Neoplasm / Apoptosis / Biomarkers / Biomarkers, Tumor / Bone marrow / CA-125 Antigen - blood / Cancer therapies / Carcinoembryonic Antigen / Cervical cancer / Chemoradiotherapy - methods / Chemotherapy / Drug dosages / Female / Humans / Immune system / Informed consent / Lifestyles / Lymphatic system / Medical prognosis / Medical screening / Metastasis / Middle Aged / Patients / Quality of Life / Radiation therapy / Serpins / Sodium / Squamous cell carcinoma / Treatment Outcome / Tumors / Uterine Cervical Neoplasms - drug therapy / Uterine Cervical Neoplasms - therapy / Vitamin B 6 - therapeutic use / Womens health