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Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis
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Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis
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Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis
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Journal Article
Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis
2000
Overview
Accumulation of fibrils composed of amyloid A in tissues resulting in displacement of normal structures and cellular dysfunction is the characteristic feature of systemic amyloidoses. Here we show that RAGE, a multiligand immunoglobulin superfamily cell surface molecule, is a receptor for the amyloidogenic form of serum amyloid A. Interactions between RAGE and amyloid A induced cellular perturbation. In a mouse model, amyloid A accumulation, evidence of cell stress and expression of RAGE were closely linked. Antagonizing RAGE suppressed cell stress and amyloid deposition in mouse spleens. These data indicate that RAGE is a potential target for inhibiting accumulation of amyloid A and for limiting cellular dysfunction induced by amyloid A.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Antigens
/ Biomedical and Life Sciences
/ Glycoproteins - pharmacology
/ Heme Oxygenase (Decyclizing) - genetics
/ Humans
/ Macrophage Colony-Stimulating Factor - genetics
/ Mice
/ Proteins
/ Rabbits
/ Receptor for Advanced Glycation End Products
/ Receptors, Immunologic - genetics
/ Receptors, Immunologic - metabolism
/ Serum Amyloid A Protein - metabolism
/ Silver Nitrate - pharmacology
/ Spleen
