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FABP5 suppresses colorectal cancer progression via mTOR-mediated autophagy by decreasing FASN expression
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FABP5 suppresses colorectal cancer progression via mTOR-mediated autophagy by decreasing FASN expression
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Journal Article
FABP5 suppresses colorectal cancer progression via mTOR-mediated autophagy by decreasing FASN expression
2023
Overview
Lipid metabolism plays an important role in the occurrence and development of cancer, in particular, digestive system tumors such as colon cancer. Here, we investigated the role of the fatty acid-binding protein 5 (
) in colorectal cancer (CRC). We observed marked down-regulation of
in CRC. Data from functional assays revealed inhibitory effects of
on cell proliferation, colony formation, migration, invasion as well as tumor growth
. In terms of mechanistic insights,
interacted with fatty acid synthase (
) and activated the ubiquitin proteasome pathway, leading to a decrease in
expression and lipid accumulation, moreover, suppressing
signaling and facilitating cell autophagy. Orlistat, a
inhibitor, exerted anti-cancer effects both
and
. Furthermore, the upstream RNA demethylase
positively regulated
expression via an m
A-independent mechanism. Overall, our collective findings offer valuable insights into the critical role of the
/
/
axis in tumor progression and uncover a potential mechanism linking lipid metabolism to development of CRC, providing novel therapeutic targets for future interventions.
Publisher
Ivyspring International Publisher Pty Ltd,Ivyspring International Publisher
Subject
/ Cell Proliferation - genetics
/ Colorectal Neoplasms - metabolism
/ Fatty Acid Synthase, Type I - genetics
/ Fatty Acid Synthase, Type I - metabolism
/ Fatty Acid Synthases - genetics
/ Fatty Acid Synthases - metabolism
/ Fatty Acid-Binding Proteins - genetics
/ Fatty Acid-Binding Proteins - metabolism
/ Humans
/ Lipids
/ Plasmids
/ Proteins
/ Reagents
/ Signal Transduction - genetics
/ TOR Serine-Threonine Kinases - metabolism
/ Tumors
