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Cannabis, Cannabinoids, and Sleep: a Review of the Literature
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Cannabis, Cannabinoids, and Sleep: a Review of the Literature
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Cannabis, Cannabinoids, and Sleep: a Review of the Literature
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Journal Article
Cannabis, Cannabinoids, and Sleep: a Review of the Literature
2017
Overview
Purpose of Review
The current review aims to summarize the state of research on cannabis and sleep up to 2014 and to review in detail the literature on cannabis and specific sleep disorders from 2014 to the time of publication.
Recent Findings
Preliminary research into cannabis and insomnia suggests that cannabidiol (CBD) may have therapeutic potential for the treatment of insomnia. Delta-9 tetrahydrocannabinol (THC) may decrease sleep latency but could impair sleep quality long-term. Novel studies investigating cannabinoids and obstructive sleep apnea suggest that synthetic cannabinoids such as nabilone and dronabinol may have short-term benefit for sleep apnea due to their modulatory effects on serotonin-mediated apneas. CBD may hold promise for REM sleep behavior disorder and excessive daytime sleepiness, while nabilone may reduce nightmares associated with PTSD and may improve sleep among patients with chronic pain.
Summary
Research on cannabis and sleep is in its infancy and has yielded mixed results. Additional controlled and longitudinal research is critical to advance our understanding of research and clinical implications.
Publisher
Springer US,Springer Nature B.V
Subject
/ Cannabis
/ Humans
/ Insomnia
/ Long Term Adverse Effects - drug therapy
/ Long Term Adverse Effects - etiology
/ Long Term Adverse Effects - psychology
/ Medicine
/ Sleep Initiation and Maintenance Disorders - drug therapy
/ Sleep Initiation and Maintenance Disorders - etiology
