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Designing CD4 immunoadhesins for AIDS therapy

by Byrn, R A , Capon, D J , Groopman, J E , Mitsuya, H , Mordenti, J , Wurm, F M , Chamow, S M , Lucas, C , Marsters, S A , Gregory, T

in Acquired immune deficiency syndrome / Acquired Immunodeficiency Syndrome - immunology / Acquired Immunodeficiency Syndrome - metabolism / Acquired Immunodeficiency Syndrome - therapy / Adjuvants, Immunologic - chemical synthesis / Adjuvants, Immunologic - metabolism / Adjuvants, Immunologic - pharmacokinetics / AIDS / Animals / Antigens, Surface - administration & dosage / Antigens, Surface - chemical synthesis / Antigens, Surface - immunology / Binding Sites, Antibody / Binding, Competitive / Blood / Cell Adhesion Molecules / Cell Line / Drug Design / Half-Life / HIV Envelope Protein gp120 / Human immunodeficiency virus 1 / Humans / Immunoglobulin G - administration & dosage / Immunoglobulin G - metabolism / Infections / Medical research / Mice / Rabbits / Receptors, Complement - analysis / Receptors, Fc - analysis / Receptors, HIV / Receptors, Virus - administration & dosage / Receptors, Virus - immunology / Retroviridae Proteins - metabolism / Viruses

1989

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Designing CD4 immunoadhesins for AIDS therapy

by Byrn, R A , Capon, D J , Groopman, J E , Mitsuya, H , Mordenti, J , Wurm, F M , Chamow, S M , Lucas, C , Marsters, S A , Gregory, T

1989

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Designing CD4 immunoadhesins for AIDS therapy

by Byrn, R A , Capon, D J , Groopman, J E , Mitsuya, H , Mordenti, J , Wurm, F M , Chamow, S M , Lucas, C , Marsters, S A , Gregory, T

1989

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Journal Article

Designing CD4 immunoadhesins for AIDS therapy

Byrn, R A,

Capon, D J,

Groopman, J E,

Mitsuya, H,

Mordenti, J,

Wurm, F M,

Chamow, S M,

Lucas, C,

Marsters, S A,

Gregory, T

1989

Overview

A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic use.

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Publisher

Nature Publishing Group

Subject

Acquired immune deficiency syndrome

/ Acquired Immunodeficiency Syndrome - immunology

/ Acquired Immunodeficiency Syndrome - metabolism

/ Acquired Immunodeficiency Syndrome - therapy

/ Adjuvants, Immunologic - chemical synthesis

/ Adjuvants, Immunologic - metabolism

/ Adjuvants, Immunologic - pharmacokinetics