Asset Details
Do you wish to reserve the book?
The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA sequencing
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA sequencing
Do you wish to request the book?
The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA sequencing
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The heterogeneity of human CD127+ innate lymphoid cells revealed by single-cell RNA sequencing
2016
Overview
Several populations of innate lymphoid cells have been identified by their cytokine and transcription factor expression. Mjösberg and colleagues report considerable heterogeneity within human tonsil innate lymphoid cell subpopulations, as revealed by single-cell RNA-sequencing profiling.
Innate lymphoid cells (ILCs) are increasingly appreciated as important participants in homeostasis and inflammation. Substantial plasticity and heterogeneity among ILC populations have been reported. Here we have delineated the heterogeneity of human ILCs through single-cell RNA sequencing of several hundreds of individual tonsil CD127
+
ILCs and natural killer (NK) cells. Unbiased transcriptional clustering revealed four distinct populations, corresponding to ILC1 cells, ILC2 cells, ILC3 cells and NK cells, with their respective transcriptomes recapitulating known as well as unknown transcriptional profiles. The single-cell resolution additionally divulged three transcriptionally and functionally diverse subpopulations of ILC3 cells. Our systematic comparison of single-cell transcriptional variation within and between ILC populations provides new insight into ILC biology during homeostasis, with additional implications for dysregulation of the immune system.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ 38/91
/ Adult
/ Aged
/ Child
/ Female
/ Humans
/ Immunity, Innate - immunology
/ Interleukin-7 Receptor alpha Subunit - metabolism
/ Killer Cells, Natural - immunology
/ Killer Cells, Natural - metabolism
/ Leukocytes, Mononuclear - immunology
/ Leukocytes, Mononuclear - metabolism
/ Lymphocyte Subsets - immunology
/ Lymphocyte Subsets - metabolism
/ Male
/ Palatine Tonsil - immunology
/ resource
We currently cannot retrieve any items related to this title. Kindly check back at a later time.