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Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study

by Khan, Iftekhar , Shafi, Seema , Veeriah, Selvaraju , Iles, Natasha , Birkbak, Nicolai Juul , Joseph, Leena , Lee, Siow-Ming , Horswell, Stuart , Adams, Haydn , ster, Martin , Lester, Jason , Langman, Gerald , Djearman, Madhav , Naidu, Babu , McGranahan, Nicholas , Mitter, Richard , Smith, Elaine , Ngai, Yenting , Morgan, Bruno , Booton, Richard , Ahmad, Tanya , Chetty, Mahendran , Swanton, Charles , Bruin, Elza de , Summers, Yvonne , Denison, Alan , Brady, Ged , Middleton, Gary , Smith, Sean , Attanoos, Richard , Fennell, Dean , Jamal-Hanjani, Mariam , Goldman, Jacki , Kerr, Keith , Dive, Caroline , Rowan, Andrew , Waller, David , Wilcox, Ben , Davies, Helen , Quezada, Sergio , Matthews, Nik , Capitano, Arrigo , Hackshaw, Alan , Taylor, Magali , Falzon, Mary , Bennett, Jonathan , Haswell, Tom , Salm, Max , Stuart, Aengus , Kornaszewska, Malgorzata , Crosbie, Philip , Quesne, John Le , Lawrence, David , Pritchard, Catrin , Wilcox, Maggie , Buchan, Keith , Blackhall, Fiona , Murugaesu, Nirupa , Woolhouse, Ian , Nonaka, Daisuke , Shaw, Jacqueline , Cobbold, Mark , Muller, Salli , MacKenzie, Mairead , Millar, Joy , Nicolson, Marianne , Remmen, Hardy , Krebs, Matthew , Peggs, Karl , Shah, Raje

in Biomedical research / Biopsy / Deoxyribonucleic acid / DNA / Drug resistance / Evolution / Genomes / Heterogeneity / Lung cancer / Medical research / Medicine / Metastasis / Patients / Studies / Tumors

2014

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2014

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2014

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Journal Article

Tracking Genomic Cancer Evolution for Precision Medicine: The Lung TRACERx Study

Khan, Iftekhar,

Shafi, Seema,

Veeriah, Selvaraju,

Iles, Natasha,

Birkbak, Nicolai Juul,

Joseph, Leena,

Lee, Siow-Ming,

Horswell, Stuart,

Adams, Haydn,

ster, Martin,

Lester, Jason,

Langman, Gerald,

Djearman, Madhav,

Naidu, Babu,

McGranahan, Nicholas,

Mitter, Richard,

Smith, Elaine,

Ngai, Yenting,

Morgan, Bruno,

Booton, Richard,

Ahmad, Tanya,

Chetty, Mahendran,

Swanton, Charles,

Bruin, Elza de,

Summers, Yvonne,

Denison, Alan,

Brady, Ged,

Middleton, Gary,

Smith, Sean,

Attanoos, Richard,

Fennell, Dean,

Jamal-Hanjani, Mariam,

Goldman, Jacki,

Kerr, Keith,

Dive, Caroline,

Rowan, Andrew,

Waller, David,

Wilcox, Ben,

Davies, Helen,

Quezada, Sergio,

Matthews, Nik,

Capitano, Arrigo,

Hackshaw, Alan,

Taylor, Magali,

Falzon, Mary,

Bennett, Jonathan,

Haswell, Tom,

Salm, Max,

Stuart, Aengus,

Kornaszewska, Malgorzata,

Crosbie, Philip,

Quesne, John Le,

Lawrence, David,

Pritchard, Catrin,

Wilcox, Maggie,

Buchan, Keith,

Blackhall, Fiona,

Murugaesu, Nirupa,

Woolhouse, Ian,

Nonaka, Daisuke,

Shaw, Jacqueline,

Cobbold, Mark,

Muller, Salli,

MacKenzie, Mairead,

Millar, Joy,

Nicolson, Marianne,

Remmen, Hardy,

Krebs, Matthew,

Peggs, Karl,

Shah, Raje

2014

Overview

The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.

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Publisher

Public Library of Science

Subject

Biomedical research

/ Biopsy

/ Deoxyribonucleic acid

/ DNA

/ Drug resistance

/ Evolution

/ Genomes